Galvez Julio, de Souza Gracioso Juliano, Camuesco Desirée, Galvez Julio, Vilegas Wagner, Monteiro Souza Brito Alba Regina, Zarzuelo Antonio
Department of Pharmacology, School of Pharmacy, University of Granada, Granada, Spain.
Fitoterapia. 2006 Dec;77(7-8):515-20. doi: 10.1016/j.fitote.2006.05.029. Epub 2006 Jul 7.
Turnera ulmifolia is a plant popularly known in Brazil and South America as chanana. Some species of Turnera are widely used in folk medicine for different types of inflammatory diseases. In this study, the preventive intestinal antiinflammatory activity of a lyophilized infusion obtained from the aerial parts of T. ulmifolia was tested in the trinitrobenzenesulphonic acid (TNBS) model of rat colitis. The results obtained revealed that pretreatment to colitic rats with the extract, at 250 and 500 mg/kg, significantly attenuated the colonic damage induced by TNBS. This beneficial effect was associated with an improvement in the colonic oxidative status, since the infusion prevented the glutathione depletion that occurred as a consequence of the colonic inflammation. On the other hand, this antioxidant activity was confirmed in in vitro studies. In conclusion, the preventive effect exerted by the lyophilized infusion of T. ulmifolia in the TNBS model of rat colitis is probably related to its antioxidant properties, due to its flavonoids content.
椭圆叶金午时花是一种在巴西和南美洲被广泛称为“查纳纳”的植物。金午时花属的一些物种在民间医学中被广泛用于治疗不同类型的炎症性疾病。在本研究中，在大鼠结肠炎的三硝基苯磺酸（TNBS）模型中测试了从椭圆叶金午时花地上部分获得的冻干浸剂的预防性肠道抗炎活性。获得的结果显示，用250和500mg/kg的提取物对结肠炎大鼠进行预处理，可显著减轻TNBS诱导的结肠损伤。这种有益效果与结肠氧化状态的改善有关，因为浸剂可防止因结肠炎症而发生的谷胱甘肽耗竭。另一方面，这种抗氧化活性在体外研究中得到了证实。总之，椭圆叶金午时花冻干浸剂在大鼠结肠炎TNBS模型中发挥的预防作用可能与其抗氧化特性有关，这归因于其黄酮类化合物含量。
