Dauphinee M J, Talal N
J Immunol. 1975 Jun;114(6):1713-6.
Antigen-induced depression of spleen DNA synthesis was studied in NZB and CBA/J mice. This phenomenon, a measure of T suppressor cell activity, normally decreases as a consequence of aging. However, NZB mice have an accelerated loss of antigen-induced depression that can be restored by treatment with thymosin or injection of 1-month-old NZB thymocytes. The restoration by thymosin declined between 1 and 2 weeks after treatment, but could be induced again after a second exposure to thymosin. These results suggest a potential for reversible but repeatable restoration of suppressor cell activity in NZB mice.
在新西兰黑鼠（NZB）和CBA/J小鼠中研究了抗原诱导的脾脏DNA合成抑制情况。这种现象是T抑制细胞活性的一种衡量指标，通常会随着衰老而降低。然而，NZB小鼠对抗原诱导的抑制作用丧失加速，而通过胸腺素治疗或注射1月龄NZB胸腺细胞可使其恢复。胸腺素治疗后的恢复在治疗后1至2周之间下降，但在再次接触胸腺素后可再次诱导恢复。这些结果表明NZB小鼠中抑制细胞活性具有可逆但可重复恢复的潜力。
