兔b4 κ链恒定区的基因多态性。
A genetic polymorphism in the constant region of rabbit b4 kappa chains.
作者信息
Sogn J A, Kindt T J
出版信息
J Exp Med. 1976 Jun 1;143(6):1475-82. doi: 10.1084/jem.143.6.1475.
Abstract
Amino acid sequence analysis of a b4 light chain from a rabbit homogeneous antistreptococcal antibody revealed the presence of two amino acid substitutions in the constant region not previously reported for these positions. These interchanges, consisting of serine for alanine at position 121 and leucine for glutamine at position 124, were also present in about 30% of the pooled b4 light chains isolated from pooled IgG from the rabbit (4539) that produced the homogeneous antibody. In addition, these interchanges (b4var) were found, always at the same levels, in varying percentages in nonimmune or early immune bleedings from related rabbits in this pedigreed family and could be traced for five generations. The inheritance pattern of b4var was consistent with autosomal codominant inheritance.
摘要
对一只兔子的同源抗链球菌抗体的b4轻链进行氨基酸序列分析发现，恒定区存在两个氨基酸替换，这些位置此前未有报道。这些互换包括第121位的丙氨酸被丝氨酸取代，以及第124位的谷氨酰胺被亮氨酸取代，在从产生该同源抗体的兔子（4539）的混合IgG中分离出的约30%的汇集b4轻链中也存在。此外，在这个纯种家族中相关兔子的非免疫或早期免疫出血中，总能以相同水平在不同百分比中发现这些互换（b4var），并且可以追溯五代。b4var的遗传模式与常染色体共显性遗传一致。
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