Farnsworth V, Goodfliesh R, Rodkey S, Hood L
Proc Natl Acad Sci U S A. 1976 Apr;73(4):1293-6. doi: 10.1073/pnas.73.4.1293.
The amino acid sequence of the constant (CK) region from the kappa immunoglobulin chains of a b9 rabbit is compared with the CK sequences, taken from the literature, of a b4 rabbit. These CK regions differ by 33% of their amino acid sequences and by three sequence insertions or deletions (sequence gaps). These extensive differences together with other published observations suggest that the b9 and b4 CK genes may not be simple alleles, but rather they may be encoded by closely linked CK genes present in every rabbit whose expression is regulated by a polymorphic control mechanism.
将b9兔κ免疫球蛋白链恒定（CK）区的氨基酸序列与文献中b4兔的CK序列进行比较。这些CK区的氨基酸序列差异为33%，且存在三个序列插入或缺失（序列间隙）。这些广泛的差异以及其他已发表的观察结果表明，b9和b4的CK基因可能不是简单的等位基因，而是可能由每只兔子中紧密连锁的CK基因编码，其表达受多态性控制机制调节。
