兔κ链的免疫球蛋白同种异型：调控紧密连锁的重复基因的一种控制机制的多态性？
Immunoglobulin allotypes of rabbit kappa chains: polymorphism of a control mechanism regulating closely linked duplicated genes?
作者信息
Farnsworth V, Goodfliesh R, Rodkey S, Hood L
出版信息
Proc Natl Acad Sci U S A. 1976 Apr;73(4):1293-6. doi: 10.1073/pnas.73.4.1293.
Abstract
The amino acid sequence of the constant (CK) region from the kappa immunoglobulin chains of a b9 rabbit is compared with the CK sequences, taken from the literature, of a b4 rabbit. These CK regions differ by 33% of their amino acid sequences and by three sequence insertions or deletions (sequence gaps). These extensive differences together with other published observations suggest that the b9 and b4 CK genes may not be simple alleles, but rather they may be encoded by closely linked CK genes present in every rabbit whose expression is regulated by a polymorphic control mechanism.
摘要
将b9兔κ免疫球蛋白链恒定（CK）区的氨基酸序列与文献中b4兔的CK序列进行比较。这些CK区的氨基酸序列差异为33%，且存在三个序列插入或缺失（序列间隙）。这些广泛的差异以及其他已发表的观察结果表明，b9和b4的CK基因可能不是简单的等位基因，而是可能由每只兔子中紧密连锁的CK基因编码，其表达受多态性控制机制调节。
相似文献
1
Immunoglobulin allotypes of rabbit kappa chains: polymorphism of a control mechanism regulating closely linked duplicated genes?兔κ链的免疫球蛋白同种异型：调控紧密连锁的重复基因的一种控制机制的多态性？
Proc Natl Acad Sci U S A. 1976 Apr;73(4):1293-6. doi: 10.1073/pnas.73.4.1293.
2
Complex allotypes of the rabbit immunoglobulin kappa light chains are encoded by structural alleles.兔免疫球蛋白κ轻链的复杂同种异型由结构等位基因编码。
Nucleic Acids Res. 1984 Jun 11;12(11):4691-701. doi: 10.1093/nar/12.11.4691.
3
[Evolution of the rabbit kappa light chain: multiple substitutions between allelic forms].[兔κ轻链的进化：等位基因形式之间的多个替换]
Ann Immunol (Paris). 1977 Jan-Mar;128(1-2):351-3.
4
Multiple sequences related to a constant-region kappa light chain gene in the rabbit genome.兔基因组中与恒定区κ轻链基因相关的多个序列。
Cell. 1982 Mar;28(3):507-13. doi: 10.1016/0092-8674(82)90205-7.
5
Kappa-chain allotypes and isotypes in the rabbit: cDNA sequences of clones encoding b9 suggest an evolutionary pathway and possible role of the interdomain disulfide bond in quantitative allotype expression.兔的κ链同种异型和同种型：编码b9的克隆的cDNA序列揭示了一种进化途径以及结构域间二硫键在定量同种异型表达中的可能作用。
Proc Natl Acad Sci U S A. 1984 Mar;81(6):1794-8. doi: 10.1073/pnas.81.6.1794.
6
Identification of rabbit immunoglobulin latent Ckappa1 allotype genes alters the concept of allelic inheritance.兔免疫球蛋白潜在Cκ1同种异型基因的鉴定改变了等位基因遗传的概念。
Mol Immunol. 1998 Oct;35(14-15):965-76. doi: 10.1016/s0161-5890(98)00081-9.
7
BASILEA rabbits express two types of immunoglobulin light chains: lambda and kappa-like.巴昔利亚兔表达两种类型的免疫球蛋白轻链：λ型和κ样型。
Proc Natl Acad Sci U S A. 1982 Jul;79(14):4391-4. doi: 10.1073/pnas.79.14.4391.
8
Proceedings: Extensive sequence differences in rabbit light chains of allotype b4 and b9.论文集：同种异型b4和b9兔轻链的广泛序列差异
Arch Int Physiol Biochim. 1975 Feb;83(1):205-6.
9
Partial amino acid sequence of a rabbit immunoglobulin light chain of allotype b5.同种异型b5兔免疫球蛋白轻链的部分氨基酸序列
Biochemistry. 1983 Feb 15;22(4):993-8. doi: 10.1021/bi00273a044.
10
Variable region correlates of group b allotypes: amino acid sequence studies of b9 L chains from homogeneous antibodies.B组同种异型的可变区相关性：来自同源抗体的b9轻链的氨基酸序列研究
Eur J Immunol. 1978 Jun;8(6):380-5. doi: 10.1002/eji.1830080603.
引用本文的文献
1
Partial amino acid sequences of mouse transplantation antigens.鼠移植抗原的部分氨基酸序列。
Immunogenetics. 1978 Dec;7(1):425-44. doi: 10.1007/BF01844033.
2
Genetic Characterization of a new allele of the rabbit group b C(k) allotypes.兔 B 群 C(k)同种异型新等位基因的遗传特征
Immunogenetics. 1978 Dec;7(1):141-7. doi: 10.1007/BF01843999.
3
Multiplicity of constant kappa light chain genes in the rabbit genome: a b4b4 homozygous rabbit contains a kappa-bas gene.兔基因组中恒定κ轻链基因的多样性：一只b4b4纯合兔含有一个κ-bas基因。
EMBO J. 1983;2(3):437-41. doi: 10.1002/j.1460-2075.1983.tb01441.x.
4
Molecular clock of silent substitution: at least six-fold preponderance of silent changes in mitochondrial genes over those in nuclear genes.沉默替换的分子钟：线粒体基因中的沉默变化比核基因中的至少多六倍。
J Mol Evol. 1982;19(1):28-35. doi: 10.1007/BF02100221.
5
BASILEA rabbits express two types of immunoglobulin light chains: lambda and kappa-like.巴昔利亚兔表达两种类型的免疫球蛋白轻链：λ型和κ样型。
Proc Natl Acad Sci U S A. 1982 Jul;79(14):4391-4. doi: 10.1073/pnas.79.14.4391.
6
The primary structure of the constant region of Basilea-rabbit immunoglobulin lambda-chains.巴塞尔兔免疫球蛋白λ链恒定区的一级结构。
Biochem J. 1981 Jul 1;197(1):177-83. doi: 10.1042/bj1970177.
7
Nucleotide sequence of constant and 3' untranslated regions of a kappa immunoglobulin light chain mRNA of a homozygous b4 rabbit.纯合b4兔κ免疫球蛋白轻链mRNA恒定区和3'非翻译区的核苷酸序列
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5802-6. doi: 10.1073/pnas.78.9.5802.
8
Multiple amino acid substitutions between murine gamma 2a heavy chain Fc regions of Ig1a and Ig1b allotypic forms.Ig1a和Ig1b同种异型形式的小鼠γ2a重链Fc区域之间存在多个氨基酸替换。
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4031-5. doi: 10.1073/pnas.78.7.4031.
9
Identification and characterization of rabbit-mouse hybridomas secreting rabbit immunoglobulin chains.分泌兔免疫球蛋白链的兔-小鼠杂交瘤的鉴定与特性分析
Proc Natl Acad Sci U S A. 1980 May;77(5):2899-903. doi: 10.1073/pnas.77.5.2899.
10
A program for prediction of protein secondary structure from nucleotide sequence data: application to histocompatibility antigens.一个从核苷酸序列数据预测蛋白质二级结构的程序：应用于组织相容性抗原。
Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):243-55. doi: 10.1093/nar/12.1part1.243.
本文引用的文献
1
Variations at the carboxyl-terminal amino acid sequence of rabbit light chains with b4, b5 and b6 allotypic specificities.具有b4、b5和b6同种异型特异性的兔轻链羧基末端氨基酸序列的变异。
J Mol Biol. 1969 May 14;41(3):473-7. doi: 10.1016/0022-2836(69)90289-7.
2
Allotypically related sequences in the Fd fragment of rabbit immunoglobulin heavy chains.兔免疫球蛋白重链Fd片段中的同种异型相关序列。
Biochem J. 1971 Sep;124(2):301-18. doi: 10.1042/bj1240301.
3
Amino acid sequence of the light chain derived from a rabbit anti-p-azobenzoate antibody of restricted heterogeneity.源自具有有限异质性的兔抗对氨基苯甲酸酯抗体的轻链氨基酸序列。
Biochem Biophys Res Commun. 1973 Aug 21;53(4):1122-9. doi: 10.1016/0006-291x(73)90581-0.
4
Mouse immunoglobulin chains. A survey of the amino-terminal sequences of kappa chains.小鼠免疫球蛋白链。κ链氨基末端序列的研究。
Biochemistry. 1973 Feb;12(4):741-9. doi: 10.1021/bi00728a026.
5
Rabbit immunoglobulin light chains: correlation of variable region sequences with allotypic markers.兔免疫球蛋白轻链：可变区序列与同种异型标记的相关性。
J Immunol. 1973 Jan;110(1):227-32.
6
Amino-acid sequence of an allotype b4 light chain from a rabbit antibody to streptococcal carbohydrate.来自兔抗链球菌碳水化合物抗体的同种异型b4轻链的氨基酸序列。
Proc Natl Acad Sci U S A. 1974 May;71(5):1995-8. doi: 10.1073/pnas.71.5.1995.
7
An active derivative of rabbit antibody light chain composed of the constant and the variable domains held together only by a native disulfide bond.一种兔抗体轻链的活性衍生物，由仅通过天然二硫键连接在一起的恒定区和可变区组成。
Proc Natl Acad Sci U S A. 1972 Sep;69(9):2495-9. doi: 10.1073/pnas.69.9.2495.
8
New genetic model for allelism at histocompatibility and other complex loci: polymorphism for control of gene expression.组织相容性及其他复杂基因座上等位性的新遗传模型：基因表达调控的多态性
Transplant Proc. 1973 Dec;5(4):1471-5.
9
Genetics of immunoglobulin kappa-chains: chemical analysis of normal human light chains of differing Inv types.免疫球蛋白κ链的遗传学：不同Inv类型正常人轻链的化学分析
Proc Natl Acad Sci U S A. 1969 May;63(1):71-7. doi: 10.1073/pnas.63.1.71.
10
A rabbit with the allotypic phenotype: ala2a3 b4b5b6.一只具有异型表型的兔子：ala2a3 b4b5b6 。
J Immunol. 1974 Oct;113(4):1313-8.
Zotero 插件