应激反应性下丘脑-垂体-肾上腺轴的反馈控制整合模型。
A feedback-controlled ensemble model of the stress-responsive hypothalamo-pituitary-adrenal axis.
作者信息
Keenan D M, Licinio J, Veldhuis J D
机构信息
Department of Statistics, University of Virginia, Charlottesville, VA 22903, USA.
出版信息
Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4028-33. doi: 10.1073/pnas.051624198. Epub 2001 Mar 13.
Abstract
The present work develops and implements a biomathematical statement of how reciprocal connectivity drives stress-adaptive homeostasis in the corticotropic (hypothalamo-pituitary-adrenal) axis. In initial analyses with this interactive construct, we test six specific a priori hypotheses of mechanisms linking circadian (24-h) rhythmicity to pulsatile secretory output. This formulation offers a dynamic framework for later statistical estimation of unobserved in vivo neurohormone secretion and within-axis, dose-responsive interfaces in health and disease. Explication of the core dynamics of the stress-responsive corticotropic axis based on secure physiological precepts should help to unveil new biomedical hypotheses of stressor-specific system failure.
摘要
本研究提出并实施了一种生物数学表述，以阐述相互连接如何驱动促肾上腺皮质激素（下丘脑 - 垂体 - 肾上腺）轴中的应激适应性稳态。在对这种交互式结构的初步分析中，我们检验了六个关于将昼夜节律（24小时）与脉冲式分泌输出联系起来的机制的特定先验假设。这种表述为后续对体内未观察到的神经激素分泌以及健康和疾病状态下轴内剂量反应界面进行统计估计提供了一个动态框架。基于可靠的生理学原理对应激反应性促肾上腺皮质激素轴的核心动态进行阐释，应有助于揭示应激源特异性系统故障的新生物医学假设。
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