产前地塞米松与出生体重降低

Antenatal dexamethasone and decreased birth weight.

作者信息

Bloom S L, Sheffield J S, McIntire D D, Leveno K J

机构信息

Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

出版信息

Obstet Gynecol. 2001 Apr;97(4):485-90. doi: 10.1016/s0029-7844(00)01206-0.

DOI:10.1016/s0029-7844(00)01206-0

PMID:11275014

Abstract

OBJECTIVE

To test the hypothesis that antenatal dexamethasone treatment to promote fetal lung maturation results in decreased birth weight corrected for gestational age.

METHODS

The birth weights of all dexamethasone-treated, singleton, live-born infants delivered at our hospital were compared with our overall obstetric population; a group of untreated infants frequency matched approximately 3:1 according to maternal race, infant sex, and gestational age at delivery; and an historical cohort of infants with an indication for dexamethasone but delivered in the 12 months before the introduction of corticosteroid therapy at our hospital.

RESULTS

Dexamethasone-treated infants (n = 961), when compared with either the overall population (n = 122,629) or matched controls (n = 2808), had significantly lower birth weights after adjustment for week of gestation (P <.001). Compared with the historical cohort of infants, the average birth weight of dexamethasone-treated infants was smaller by 12 g at 24-26 weeks, 63 g at 27-29 weeks, 161 g at 30-32 weeks, and 80 g at 33-34 weeks' gestation.

CONCLUSION

Antenatal dexamethasone administered to promote fetal maturation is associated with diminished birth weight.

摘要

目的

验证产前使用地塞米松促进胎儿肺成熟会导致经孕周校正后的出生体重降低这一假说。

方法

将我院所有接受地塞米松治疗的单胎活产婴儿的出生体重与我院总体产科人群进行比较；根据产妇种族、婴儿性别和分娩时的孕周，将一组未治疗的婴儿按约3:1的比例进行频率匹配；并与我院在引入皮质类固醇治疗前12个月内有地塞米松使用指征但已分娩的婴儿历史队列进行比较。

结果

与总体人群（n = 122,629）或匹配对照组（n = 2808）相比，接受地塞米松治疗的婴儿（n = 961）在调整孕周后出生体重显著更低（P <.001）。与婴儿历史队列相比，接受地塞米松治疗的婴儿在孕24 - 26周时平均出生体重小12克，孕27 - 29周时小63克，孕30 - 32周时小161克，孕33 - 34周时小80克。