接受激素替代疗法的无症状绝经后妇女宫颈细胞学检查中“正常”子宫内膜细胞的意义。
Significance of "normal" endometrial cells in cervical cytology from asymptomatic postmenopausal women receiving hormone replacement therapy.
作者信息
Montz F J
机构信息
The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, The Johns Hopkins Hospital and Medical Institutions, 600 North Wolfe Street, Baltimore, Maryland 21287-1248, USA.
出版信息
Gynecol Oncol. 2001 Apr;81(1):33-9. doi: 10.1006/gyno.2000.6106.
OBJECTIVE
The aim of this study is to assess the significance of normal endometrial cells identified in screening Pap smears from asymptomatic postmenopausal women taking hormone replacement therapy (HRT).
METHODS
Endometrial histology reported from 93 asymptomatic postmenopausal women receiving HRT noted to have normal endometrial cells on a screening Pap smear was reviewed. Information regarding HRT, endometrial sampling, and interval between the sentinel Pap and sampling was extracted from the record.
RESULTS
Endometrial biopsies were obtained an average of 1.7 months after the Pap smears. Eighteen of the ninety-three histology specimens (19%, 95% CI: 12--27%) identified abnormalities, in four cases precancerous or cancerous lesions. These 18 abnormalities included 7 endometrial polyps; 7 cases of simple hyperplasia, 1 with atypia; 3 cases of complex hyperplasia, 1 with atypia; and 1 endometrial adenocarcinoma.
CONCLUSION
Normal endometrial cells identified on a screening Pap smear in this population may be an indication of endometrial disease.
目的
本研究旨在评估在接受激素替代疗法（HRT）的无症状绝经后妇女的巴氏涂片筛查中发现的正常子宫内膜细胞的意义。
方法
回顾了93名接受HRT的无症状绝经后妇女的子宫内膜组织学报告，这些妇女在巴氏涂片筛查中被发现有正常子宫内膜细胞。从记录中提取了有关HRT、子宫内膜取样以及初次巴氏涂片和取样之间间隔的信息。
结果
子宫内膜活检平均在巴氏涂片后1.7个月进行。93个组织学标本中有18个（19%，95%可信区间：12 - 27%）发现异常，其中4例为癌前病变或癌性病变。这18例异常包括7例子宫内膜息肉；7例单纯性增生，其中1例有异型性；3例复杂性增生，其中1例有异型性；以及1例子宫内膜腺癌。
结论
在该人群的巴氏涂片筛查中发现的正常子宫内膜细胞可能提示子宫内膜疾病。
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