分子遗传学时代的精神分裂症遗传咨询
Genetic counselling for schizophrenia in the era of molecular genetics.
作者信息
Hodgkinson K A, Murphy J, O'Neill S, Brzustowicz L, Bassett A S
机构信息
Genetics Department, Memorial University of Newfoundland, St John's, Newfoundland.
出版信息
Can J Psychiatry. 2001 Mar;46(2):123-30. doi: 10.1177/070674370104600202.
OBJECTIVE
To review the role of genetic counselling for individuals with psychiatric illnesses.
METHOD
Using schizophrenia as an example and including updated information about a genetic subtype (22q deletion syndrome), we discuss the value of the genetic counselling process in psychiatry, with support from the literature and our clinical experience.
RESULTS
Genetic counselling, the process through which knowledge about the genetics of illnesses is shared, provides information on the inheritance of illnesses and their recurrence risks; addresses the concerns of patients, their families, and their health care providers; and supports patients and their families dealing with these illnesses. For comprehensive medical management, this service should be available to all individuals with schizophrenia and their families.
CONCLUSIONS
New findings in the genetics of psychiatric illness may have important clinical implications for patients and their families.
目的
探讨遗传咨询对精神疾病患者的作用。
方法
以精神分裂症为例，并纳入有关一种遗传亚型（22q缺失综合征）的最新信息，我们结合文献及临床经验讨论遗传咨询过程在精神病学中的价值。
结果
遗传咨询是分享疾病遗传学知识的过程，它提供疾病遗传及复发风险的信息；解决患者、其家人及医疗服务提供者的担忧；并支持患者及其家人应对这些疾病。为实现全面医疗管理，应向所有精神分裂症患者及其家人提供此项服务。
结论
精神疾病遗传学的新发现可能对患者及其家人具有重要的临床意义。
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