Parsad D, Pandhi R, Nagpal R, Negi K S
Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
J Dermatol. 2001 Jan;28(1):1-4. doi: 10.1111/j.1346-8138.2001.tb00077.x.
Acne vulgaris is a common skin disease seen primarily in adolescent and young adults. As the treatment involves long term therapy with antibiotics, an agent with a long half life can be very useful in increasing the compliance. To evaluate the role of a monthly dose of azithromycin and compare it with daily doxycycline, we conducted this randomized comparative study. Sixty patients with moderate to severe acne were randomly assigned to two treatment groups, A & B. Patients in group A received 100 mg doxycycline daily in addition to topical 0.05% tretinoin cream, whereas patients in group B were given 500 mg azithromycin once a day for four days per month along with 0.05% topical tretinoin for a total of 12 weeks. Of the 60 patients, 22 in group A and 28 in group B were evaluated. The monthly dose of azithromycin was found to be as effective as daily doxycycline on a pure protocol basis and statistically significantly better than doxycycline by intention to treat analysis.
寻常痤疮是一种主要见于青少年和青年成年人的常见皮肤病。由于治疗需要长期使用抗生素，一种半衰期长的药物在提高依从性方面可能非常有用。为了评估每月一剂阿奇霉素的作用并将其与每日服用强力霉素进行比较，我们开展了这项随机对照研究。60例中度至重度痤疮患者被随机分为A、B两个治疗组。A组患者除外用0.05%维甲酸乳膏外，每日服用100mg强力霉素，而B组患者每月连续4天每天服用500mg阿奇霉素，同时外用0.05%维甲酸，共治疗12周。60例患者中，对A组的22例和B组的28例进行了评估。在单纯方案基础上，发现每月一剂阿奇霉素与每日服用强力霉素效果相当，且在意向性治疗分析中，阿奇霉素在统计学上显著优于强力霉素。
