阿奇霉素治疗寻常痤疮的疗效：一篇综述
Efficacy of Azithromycin in Treatment of Acne Vulgaris: A Mini Review.
作者信息
Kardeh Sina, Saki Nasrin, Jowkar Farideh, Kardeh Bahareh, Moein Seyed Arman, Khorraminejad-Shirazi Mohammad Hossein
机构信息
Cellular and Molecular Medicine Student Research Group, School of Medicine, Shiraz University of Medical Science, Shiraz, Iran.
Molecular Dermatology Research Center, Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
World J Plast Surg. 2019 May;8(2):127-134. doi: 10.29252/wjps.8.2.127.
Abstract
BACKGROUND
Antibiotics are commonly used in the treatment of acne vulgaris. Considering the rise of antibiotic resistance, alternative medications may be used in the main anti-acne armamentarium. The aim of this study was to investigate the efficacy of oral azithromycin in the treatment of acne vulgaris.
METHODS
Database searches were performed in PubMed and Scopus using the keywords "azithromycin" and "acne".
RESULTS
Azithromycin 500 mg once daily for 3 days per week or in cycles of 10 days for 12 weeks are the most commonly used regimens.
CONCLUSION
Available experimental data suggest that oral azithromycin is an effective and well-tolerated option for treatment of acne vulgaris.
摘要
背景
抗生素常用于寻常痤疮的治疗。鉴于抗生素耐药性的增加，替代药物可能会被纳入主要的抗痤疮药物库。本研究的目的是调查口服阿奇霉素治疗寻常痤疮的疗效。
方法
在PubMed和Scopus数据库中使用关键词“阿奇霉素”和“痤疮”进行检索。
结果
最常用的治疗方案是每周3天，每天一次服用500毫克阿奇霉素，或每10天为一个周期，持续12周。
结论
现有实验数据表明，口服阿奇霉素是治疗寻常痤疮的一种有效且耐受性良好的选择。
相似文献
1
Efficacy of Azithromycin in Treatment of Acne Vulgaris: A Mini Review.
World J Plast Surg. 2019 May;8(2):127-134. doi: 10.29252/wjps.8.2.127.
2
Comparison of therapeutic effects of oral doxycycline and azithromycin in patients with moderate acne vulgaris: What is the role of age?
J Dermatolog Treat. 2011 Aug;22(4):206-10. doi: 10.3109/09546631003762639. Epub 2010 Jul 29.
3
Comparison of the Efficacy of Azithromycin Versus Doxycycline in Acne Vulgaris: A Meta-Analysis of Randomized Controlled Trials.
Ann Dermatol. 2018 Aug;30(4):417-426. doi: 10.5021/ad.2018.30.4.417. Epub 2018 Jun 28.
4
Azithromycin versus tetracycline in the treatment of acne vulgaris.
J Dermatolog Treat. 2006;17(4):217-21. doi: 10.1080/09546630600866459.
5
Comparison of oral azithromycin with oral doxycycline in the treatment of acne vulgaris.
J Ayub Med Coll Abbottabad. 2014 Jan-Mar;26(1):64-7.
6
Comparison of efficacy of azithromycin vs. doxycycline in the treatment of acne vulgaris.
Clin Exp Dermatol. 2005 May;30(3):215-20. doi: 10.1111/j.1365-2230.2005.01769.x.
7
Comparison of oral azithromycin pulse with daily doxycycline in the treatment of acne vulgaris.
Indian J Dermatol Venereol Leprol. 2003 Jul-Aug;69(4):274-6.
8
Comparative Effects of Azithromycin and Probiotics for Treatment of Acne Vulgaris.
J Coll Physicians Surg Pak. 2023 May;33(5):516-520. doi: 10.29271/jcpsp.2023.05.516.
9
Azithromycin monthly pulse vs daily doxycycline in the treatment of acne vulgaris.
J Dermatol. 2001 Jan;28(1):1-4. doi: 10.1111/j.1346-8138.2001.tb00077.x.
10
Azithromycin for the treatment of acne.
Int J Dermatol. 2000 Jan;39(1):45-50. doi: 10.1046/j.1365-4362.2000.00749.x.
引用本文的文献
1
PRACT-India: Practical Recommendations on Acne Care and Medical Treatment in India-A Modified Delphi Consensus.
Antibiotics (Basel). 2025 Aug 20;14(8):844. doi: 10.3390/antibiotics14080844.
2
Impact of azithromycin on specific biochemical markers and sebum composition in acne vulgaris patients.
Arch Dermatol Res. 2025 Jun 5;317(1):798. doi: 10.1007/s00403-025-04299-4.
3
Decoding Acne Vulgaris: Insights into Pathogenesis, Treatment Modalities, Diagnosis and Recent Advancements.
Recent Adv Inflamm Allergy Drug Discov. 2025;19(1):18-30. doi: 10.2174/0127722708312980240718093537.
4
Efficacy of Topical Treatments in the Management of Mild-to-Moderate Acne Vulgaris: A Systematic Review.
Cureus. 2024 Apr 9;16(4):e57909. doi: 10.7759/cureus.57909. eCollection 2024 Apr.
5
larvae: A novel source for combating broad-spectrum bacterial and fungal infections.
Vet World. 2024 Jan;17(1):156-170. doi: 10.14202/vetworld.2024.156-170. Epub 2024 Jan 20.
6
Azithromycin Treatment for Acne Vulgaris: A Case Report on the Risk of Clostridioides difficile Infection.
Am J Case Rep. 2023 Nov 20;24:e941424. doi: 10.12659/AJCR.941424.
7
Treatment of Acne Vulgaris During Pregnancy and Lactation: A Narrative Review.
Dermatol Ther (Heidelb). 2023 Jan;13(1):115-130. doi: 10.1007/s13555-022-00854-3. Epub 2022 Nov 29.
8
Formulation and Evaluation of Azithromycin-Loaded Niosomal Gel: Optimization, In Vitro Studies, Rheological Characterization, and Cytotoxicity Study.
ACS Omega. 2022 Oct 25;7(44):39782-39793. doi: 10.1021/acsomega.2c03762. eCollection 2022 Nov 8.
9
Going, Toll-like receptors in skin inflammation and inflammatory diseases.
EXCLI J. 2021 Jan 7;20:52-79. doi: 10.17179/excli2020-3114. eCollection 2021.
10
Potential harms of long-term acne treatment with oral antibiotics.
Can Fam Physician. 2020 Sep;66(9):669-670.
本文引用的文献
1
Azithromycin impairs TLR7 signaling in dendritic cells and improves the severity of imiquimod-induced psoriasis-like skin inflammation in mice.
J Dermatol Sci. 2016 Oct;84(1):59-70. doi: 10.1016/j.jdermsci.2016.07.007. Epub 2016 Jul 12.
2
The SAPHO syndrome: a single-center study of 41 adult patients.
J Rheumatol. 2015 Feb;42(2):329-34. doi: 10.3899/jrheum.140342. Epub 2014 Dec 15.
3
Comparison of oral azithromycin with oral doxycycline in the treatment of acne vulgaris.
J Ayub Med Coll Abbottabad. 2014 Jan-Mar;26(1):64-7.
4
Azithromycin: mechanisms of action and their relevance for clinical applications.
Pharmacol Ther. 2014 Aug;143(2):225-45. doi: 10.1016/j.pharmthera.2014.03.003. Epub 2014 Mar 11.
5
Treatment of acne vulgaris during pregnancy and lactation.
Drugs. 2013 Jun;73(8):779-87. doi: 10.1007/s40265-013-0060-0.
6
Acne vulgaris.
BMJ. 2013 May 8;346:f2634. doi: 10.1136/bmj.f2634.
7
Superior efficacy of azithromycin and levamisole vs. azithromycin in the treatment of inflammatory acne vulgaris: an investigator blind randomized clinical trial on 169 patients.
Int J Clin Pharmacol Ther. 2013 Jun;51(6):490-4. doi: 10.5414/CP201861.
8
Combination of low-dose isotretinoin and pulsed oral azithromycin for maximizing efficacy of acne treatment.
Mymensingh Med J. 2013 Jan;22(1):42-8.
9
Macrolides in chronic inflammatory skin disorders.
Mediators Inflamm. 2012;2012:159354. doi: 10.1155/2012/159354. Epub 2012 May 17.
10
Acne vulgaris.
Lancet. 2012 Jan 28;379(9813):361-72. doi: 10.1016/S0140-6736(11)60321-8. Epub 2011 Aug 29.
Zotero 插件