• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

市售丙型肝炎病毒抗体检测中反应性的相关性。

Relevance of reactivity in commercially available hepatitis C virus antibody assays.

作者信息

Polywka S, Schröter M, Feucht H H, Zöllner B, Laufs R

出版信息

J Clin Microbiol. 2001 Apr;39(4):1665-8. doi: 10.1128/JCM.39.4.1665-1668.2001.

DOI:10.1128/JCM.39.4.1665-1668.2001
PMID:11283113
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC87996/
Abstract

Sera from 2,148 patients were tested with a third-generation microparticle enzyme immunoassay (MEIA), a confirmatory assay, and a reverse transcription-PCR. Overall, 85.6% of reactivities were confirmed, 13.2% were shown to be unspecifically reactive, and 1.2% were indeterminate. The rate of confirmed MEIA reactivities clearly depended on the strength of the reactivity.

摘要

对2148名患者的血清进行了第三代微粒体酶免疫测定（MEIA）、确证测定和逆转录聚合酶链反应检测。总体而言，85.6%的反应性得到确证，13.2%显示为非特异性反应，1.2%为不确定反应。MEIA确证反应性的比率明显取决于反应性的强度。

相似文献

1
Relevance of reactivity in commercially available hepatitis C virus antibody assays.市售丙型肝炎病毒抗体检测中反应性的相关性。
J Clin Microbiol. 2001 Apr;39(4):1665-8. doi: 10.1128/JCM.39.4.1665-1668.2001.
2
Quantitative signal of anti-HCV by an automated assay predicts viremia in a population at high prevalence of hepatitis C virus infection.通过自动化检测法检测的抗丙型肝炎病毒定量信号可预测丙型肝炎病毒感染高流行人群中的病毒血症。
J Clin Virol. 2004 May;30(1):45-9. doi: 10.1016/j.jcv.2003.08.007.
3
Evaluation and comparison of three different anti-hepatitis C virus antibody tests based on chemiluminescence and enzyme-linked immunosorbent assay methods used in the diagnosis of hepatitis C infections in Turkey.基于化学发光和酶联免疫吸附测定方法的三种不同抗丙型肝炎病毒抗体检测在土耳其丙型肝炎感染诊断中的评估与比较。
J Int Med Res. 2009 Sep-Oct;37(5):1420-9. doi: 10.1177/147323000903700516.
4
Evaluation of third-generation assays for detection of anti-hepatitis C virus (HCV) antibodies and comparison with presence of HCV RNA in blood donors reactive to c100-3 antigen.用于检测抗丙型肝炎病毒（HCV）抗体的第三代检测方法的评估以及与对c100-3抗原呈反应性的献血者血液中HCV RNA存在情况的比较。
J Clin Microbiol. 1994 Sep;32(9):2272-5. doi: 10.1128/jcm.32.9.2272-2275.1994.
5
Indeterminate third-generation hepatitis C recombinant immunoblot assay and HCV RNA analysis: isolated reactivity against NS5 associated with HCV viraemia in clinical patients but not blood donors.不确定的第三代丙型肝炎重组免疫印迹试验及丙型肝炎病毒RNA分析：临床患者中针对NS5的孤立反应性与丙型肝炎病毒血症相关，但献血者中不存在这种情况。
Scand J Infect Dis. 2005;37(6-7):488-92. doi: 10.1080/00365540510037821.
6
Detection of antibodies to hepatitis C virus: false-negative results in an automated chemiluminescent microparticle immunoassay (ARCHITECT Anti-HCV) compared to a microparticle enzyme immunoassay (AxSYM HCV Version 3.0).丙型肝炎病毒抗体检测：与微粒酶免疫测定法（AxSYM HCV版本3.0）相比，自动化化学发光微粒免疫测定法（ARCHITECT Anti-HCV）中的假阴性结果
J Clin Virol. 2005 Nov;34(3):211-5; discussion 216-8. doi: 10.1016/j.jcv.2005.05.013. Epub 2005 Aug 19.
7
Diverse patterns of recognition of hepatitis C virus core and nonstructural antigens by antibodies present in Egyptian cancer patients and blood donors.埃及癌症患者和献血者体内抗体对丙型肝炎病毒核心抗原和非结构抗原的不同识别模式。
J Clin Microbiol. 1996 Nov;34(11):2665-9. doi: 10.1128/jcm.34.11.2665-2669.1996.
8
Evaluation of a rapid assay as an alternative to conventional enzyme immunoassays for detection of hepatitis C virus-specific antibodies.评估一种快速检测方法作为传统酶免疫测定法检测丙型肝炎病毒特异性抗体的替代方法。
J Clin Microbiol. 2005 Apr;43(4):1977-8. doi: 10.1128/JCM.43.4.1977-1978.2005.
9
Evaluation of a supplemental assay for the diagnosis of hepatitis C virus infections.用于丙型肝炎病毒感染诊断的补充检测方法评估
Int J Infect Dis. 2000;4(1):42-5. doi: 10.1016/s1201-9712(00)90065-1.
10
Strategies for reliable diagnosis of hepatitis C infection: the need for a serological confirmatory assay.丙型肝炎感染的可靠诊断策略：血清学确证检测的必要性。
J Med Virol. 2001 Jul;64(3):320-4. doi: 10.1002/jmv.1053.

引用本文的文献

1
Establishing a sample-to cut-off ratio for lab-diagnosis of hepatitis C virus in Indian context.在印度背景下建立用于丙型肝炎病毒实验室诊断的样本与临界值比率。
Asian J Transfus Sci. 2015 Jul-Dec;9(2):185-8. doi: 10.4103/0973-6247.154259.
2
Laboratory diagnosis of viral hepatitis C: The Sultan Qaboos University Hospital experience.丙型病毒性肝炎的实验室诊断：苏丹卡布斯大学医院的经验
J Sci Res Med Sci. 2003 Aug;5(1-2):15-20.
3
Enzyme-linked immunosorbent/chemiluminescence assays, recombinant immunoblot assays and nucleic acid tests in the diagnosis of HCV infection.酶联免疫吸附/化学发光测定法、重组免疫印迹测定法和核酸检测在 HCV 感染诊断中的应用。
Eur J Clin Microbiol Infect Dis. 2013 Aug;32(8):985-8. doi: 10.1007/s10096-013-1857-1. Epub 2013 May 11.
4
Significance of anti-HCV signal-to-cutoff ratio in predicting hepatitis C viremia.抗 HCV 信号-截止值比值在预测丙型肝炎病毒血症中的意义。
Korean J Intern Med. 2009 Dec;24(4):302-8. doi: 10.3904/kjim.2009.24.4.302. Epub 2009 Nov 27.
5
Hepatitis A, B, and C.甲型、乙型和丙型肝炎。
Sex Transm Infect. 2006 Dec;82 Suppl 4(Suppl 4):iv35-9. doi: 10.1136/sti.2006.023218.
6
Qualitative detection of hepatitis C virus RNA: comparison of analytical sensitivity, clinical performance, and workflow of the Cobas Amplicor HCV test version 2.0 and the HCV RNA transcription-mediated amplification qualitative assay.丙型肝炎病毒RNA的定性检测：Cobas Amplicor HCV检测试剂盒2.0版与HCV RNA转录介导的扩增定性检测方法的分析灵敏度、临床性能及工作流程比较
J Clin Microbiol. 2002 Aug;40(8):2903-7. doi: 10.1128/JCM.40.8.2903-2907.2002.

本文引用的文献

1
Quantitative detection of hepatitis C virus RNA by light cycler PCR and comparison with two different PCR assays.运用荧光定量PCR技术对丙型肝炎病毒RNA进行定量检测，并与两种不同的PCR检测方法进行比较。
J Clin Microbiol. 2001 Feb;39(2):765-8. doi: 10.1128/JCM.39.2.765-768.2001.
2
High rate of chronicity in HCV infection determined by antibody confirmatory assay and PCR in 4110 patients during long-term follow-up.在4110例患者的长期随访中，通过抗体确证试验和PCR检测确定丙型肝炎病毒（HCV）感染的慢性化率较高。
J Clin Virol. 1999 Jun;13(1-2):43-51. doi: 10.1016/s1386-6532(99)00005-0.
3
Serological determination of hepatitis C virus subtypes 1a, 1b, 2a, 2b, 3a, and 4a by a recombinant immunoblot assay.通过重组免疫印迹法对丙型肝炎病毒1a、1b、2a、2b、3a和4a亚型进行血清学测定。
J Clin Microbiol. 1999 Aug;37(8):2576-80. doi: 10.1128/JCM.37.8.2576-2580.1999.
4
Definition of false-positive reactions in screening for hepatitis C virus antibodies.丙型肝炎病毒抗体筛查中假阳性反应的定义。
J Clin Microbiol. 1999 Jan;37(1):233-4. doi: 10.1128/JCM.37.1.233-234.1999.
5
High percentage of seronegative HCV infections in hemodialysis patients: the need for PCR.血液透析患者中丙型肝炎病毒血清学阴性感染的高比例：对聚合酶链反应检测的需求。
Intervirology. 1997;40(4):277-8. doi: 10.1159/000150558.
6
Influence of viraemia and genotype upon serological reactivity in screening assays for antibody to hepatitis C virus.丙型肝炎病毒抗体筛查试验中病毒血症和基因型对血清学反应性的影响。
J Med Virol. 1996 Feb;48(2):184-90. doi: 10.1002/(SICI)1096-9071(199602)48:2<184::AID-JMV11>3.0.CO;2-F.
7
Hepatitis C virus antibody prevalence among human immunodeficiency virus-1-infected individuals: analysis with different test systems.人类免疫缺陷病毒1型感染者中丙型肝炎病毒抗体流行率：不同检测系统的分析
J Med Virol. 1994 Sep;44(1):49-53. doi: 10.1002/jmv.1890440110.
8
Study on reliability of commercially available hepatitis C virus antibody tests.市售丙型肝炎病毒抗体检测的可靠性研究。
J Clin Microbiol. 1995 Mar;33(3):620-4. doi: 10.1128/jcm.33.3.620-624.1995.
9
Second generation hepatitis C virus assays: performance when testing African sera.第二代丙型肝炎病毒检测方法：检测非洲血清时的性能
J Med Virol. 1993 Sep;41(1):35-8. doi: 10.1002/jmv.1890410108.
10
Recombinant immunoblot assay reaction patterns and hepatitis C virus RNA in blood donors and non-A, non-B hepatitis patients.献血者和非甲非乙型肝炎患者的重组免疫印迹试验反应模式及丙型肝炎病毒RNA
Transfusion. 1993 Aug;33(8):634-8. doi: 10.1046/j.1537-2995.1993.33893342743.x.