Haze S, Gozu Y, Nakamura S, Kohno Y, Sawano K, Ohta H, Yamazaki K
Shiseido Co. Ltd., Product Development Center, Yokohama, Japan.
J Invest Dermatol. 2001 Apr;116(4):520-4. doi: 10.1046/j.0022-202x.2001.01287.x.
Human body odor consists of various kinds of odor components. Here, we have investigated the changes in body odor associated with aging. The body odor of subjects between the ages of 26 and 75 was analyzed by headspace gas chromatography/mass spectrometry. 2-Nonenal, an unsaturated aldehyde with an unpleasant greasy and grassy odor, was detected only in older subjects (40 y or older). Furthermore, analysis of skin surface lipids revealed that omega7 unsaturated fatty acids and lipid peroxides also increased with aging and that there were positive correlations between the amount of 2-nonenal in body odor and the amount of omega7 unsaturated fatty acids or lipid peroxides in skin surface lipids. 2-Nonenal was generated only when omega7 unsaturated fatty acids were degraded by degradation tests in which some main components of skin surface lipids were oxidatively decomposed using lipid peroxides as initiator of an oxidative chain reaction. The results indicate that 2-nonenal is generated by the oxidative degradation of omega7 unsaturated fatty acids, and suggest that 2-nonenal may be involved in the age-related change of body odor.
人体气味由各种气味成分组成。在此，我们研究了与衰老相关的体臭变化。通过顶空气相色谱/质谱法分析了26至75岁受试者的体臭。2-壬烯醛是一种具有难闻油腻和草腥味的不饱和醛，仅在老年受试者（40岁及以上）中检测到。此外，对皮肤表面脂质的分析表明，ω-7不饱和脂肪酸和脂质过氧化物也随着衰老而增加，并且体臭中2-壬烯醛的含量与皮肤表面脂质中ω-7不饱和脂肪酸或脂质过氧化物的含量之间存在正相关。在降解试验中，当以脂质过氧化物作为氧化链反应的引发剂氧化分解皮肤表面脂质的一些主要成分时，仅在ω-7不饱和脂肪酸降解时才产生2-壬烯醛。结果表明，2-壬烯醛是由ω-7不饱和脂肪酸的氧化降解产生的，这表明2-壬烯醛可能与体臭的年龄相关变化有关。
