AP-1阻遏蛋白JDP-2：通过下调p53抑制紫外线介导的细胞凋亡。
AP-1 repressor protein JDP-2: inhibition of UV-mediated apoptosis through p53 down-regulation.
作者信息
Piu F, Aronheim A, Katz S, Karin M
机构信息
Department of Pharmacology, Laboratory of Gene Regulation and Signal Transduction, , University of California at San Diego, La Jolla, California 92093-0636, USA.
出版信息
Mol Cell Biol. 2001 May;21(9):3012-24. doi: 10.1128/MCB.21.9.3012-3024.2001.
Abstract
Members of the AP-1 transcription factor family, especially c-Jun and c-Fos, have long been known to mediate critical steps in the cellular response to ultraviolet (UV) irradiation. We sought to examine whether two newly discovered members of the AP-1 family, JDP-1 and JDP-2, also participate in the mammalian UV response. Here we report that JDP-2, but not JDP-1, is transiently induced upon UV challenge and that elevated levels of JDP-2 increase cell survival following UV exposure. This protective function of JDP-2 appears to be mediated through repression of p53 expression at the transcriptional level, via a conserved atypical AP-1 site in the p53 promoter.
摘要
长期以来，人们一直认为AP-1转录因子家族的成员，尤其是c-Jun和c-Fos，在细胞对紫外线（UV）照射的反应中介导关键步骤。我们试图研究AP-1家族的两个新发现成员JDP-1和JDP-2是否也参与哺乳动物的UV反应。在此我们报告，JDP-2而非JDP-1在UV刺激后被短暂诱导，并且JDP-2水平升高可增加UV照射后的细胞存活率。JDP-2的这种保护功能似乎是通过p53启动子中一个保守的非典型AP-1位点在转录水平上抑制p53表达来介导的。
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本文引用的文献
1
The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest.哺乳动物的紫外线反应：从p53诱导的生长停滞状态退出需要c-Jun的诱导。
Cell. 2000 Dec 8;103(6):897-907. doi: 10.1016/s0092-8674(00)00193-8.
2
UV-Induced stabilization of c-fos and other short-lived mRNAs.紫外线诱导的c-fos及其他短寿命信使核糖核酸的稳定性
Mol Cell Biol. 2000 May;20(10):3616-25. doi: 10.1128/MCB.20.10.3616-3625.2000.
3
Regulation and function of the p53-related proteins: same family, different rules.p53相关蛋白的调控与功能：同一家族，不同规则。
Trends Cell Biol. 2000 May;10(5):197-202. doi: 10.1016/s0962-8924(00)01736-0.
4
CD95 (Fas/APO-1) and p53 signal apoptosis independently in diverse cell types.CD95（Fas/APO-1）和p53在多种细胞类型中独立诱导细胞凋亡。
Cancer Res. 2000 Mar 1;60(5):1217-20.
5
The p53 pathway and apoptosis.
J Cell Physiol. 1999 Nov;181(2):231-9. doi: 10.1002/(SICI)1097-4652(199911)181:2<231::AID-JCP5>3.0.CO;2-L.
6
Mechanisms of p53-induced apoptosis.p53诱导细胞凋亡的机制。
Biochem Pharmacol. 1999 Oct 1;58(7):1089-95. doi: 10.1016/s0006-2952(99)00153-7.
7
Control of cell cycle progression by c-Jun is p53 dependent.c-Jun 对细胞周期进程的调控依赖于 p53。
Genes Dev. 1999 Mar 1;13(5):607-19. doi: 10.1101/gad.13.5.607.
8
Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions.通过一种检测蛋白质-蛋白质相互作用的新方法分离出一种AP-1阻遏物。
Mol Cell Biol. 1997 Jun;17(6):3094-102. doi: 10.1128/MCB.17.6.3094.
9
Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo.携带p53反应性lacZ的转基因小鼠：p53活性在正常发育过程中变化显著，并决定体内的辐射和药物敏感性。
EMBO J. 1997 Mar 17;16(6):1391-400. doi: 10.1093/emboj/16.6.1391.
10
Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation.在炎症过程中，丝裂原活化蛋白激酶p38对转录因子MEF2C的激活作用。
Nature. 1997 Mar 20;386(6622):296-9. doi: 10.1038/386296a0.
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