Zhu Lü-Yun, Hu Li-Ye, Li Xiao-Ling
Department of Endocrinology, Bethune International Peace Hospital, Shijiazhuang 050082, China.
Zhonghua Nei Ke Za Zhi. 2008 Oct;47(10):811-4.
To investigate the relationship between Trp64Arg mutation in beta(3)-adrenergic receptor (beta(3)-AR) gene and the incidence of metabolic syndrome (MS).
A seven-year follow-up study was conducted in 386 simple obese subjects and 175 normal weight subjects in whom geno-typing of Trp64Arg mutation in beta(3)-AR gene was examined in 2000.
There were no differences between a Trp64Trp homozygote group and a Trp64Arg heterozygote group of whether obese or normal weight subjects with respect to adiposity, blood pressure, lipid profile, fasting blood glucose and fasting insulin in the baseline. The results of follow-up indicated that the incidence of MS in the Trp64Arg heterozygote group was higher than that in the Trp64Trp homozygote group of obese males (54.76% vs 40.85%, P < 0.05) but not in the group of obese females. The incidences of MS both in the Trp64Trp homozygote group and Trp64Arg heterozygote group were higher in obese males than in obese females (40.85% vs 18.27% and 54.76% vs 21.28%, all P < 0.01). No significant differences were found in incidences of MS both in the Trp64Trp homozygote group and Trp64Arg heterozygote group of normal weight subjects whether the comparison was made between males and females respectively or between males and females. The overall incidence of MS in the obese subjects were significantly increased than that in the normal weight subjects whether there was gene variant or not (31.30% vs 6.03% and 42.75% vs 12.73%, all P < 0.01). Logistic analysis showed that beta(3)-AR gene variant was associated with increased incidence of MS in males.
beta(3)-AR gene Trp64Arg mutation is an independent risk factor for the incidence of MS in males.
探讨β3-肾上腺素能受体（β3-AR）基因Trp64Arg突变与代谢综合征（MS）发病率之间的关系。
对386例单纯肥胖受试者和175例正常体重受试者进行了为期7年的随访研究，于2000年检测了β3-AR基因Trp64Arg突变的基因分型。
在基线时，无论是肥胖还是正常体重的受试者，Trp64Trp纯合子组和Trp64Arg杂合子组在肥胖程度、血压、血脂谱、空腹血糖和空腹胰岛素方面均无差异。随访结果表明，肥胖男性中Trp64Arg杂合子组的MS发病率高于Trp64Trp纯合子组（54.76%对40.85%，P<0.05），但肥胖女性组中无此差异。肥胖男性中Trp64Trp纯合子组和Trp64Arg杂合子组的MS发病率均高于肥胖女性（40.85%对18.27%和54.76%对21.28%，均P<0.01）。正常体重受试者中，Trp64Trp纯合子组和Trp64Arg杂合子组的MS发病率在男女之间比较均无显著差异。无论是否存在基因变异，肥胖受试者的MS总体发病率均显著高于正常体重受试者（31.30%对6.03%和42.75%对12.73%，均P<0.01）。Logistic分析显示，β3-AR基因变异与男性MS发病率增加相关。
β3-AR基因Trp64Arg突变是男性MS发病的独立危险因素。
