Pinter J D, Brown W E, Eliez S, Schmitt J E, Capone G T, Reiss A L
Department of Neurology, University of Washington School of Medicine, Seattle, USA.
Neurology. 2001 Apr 10;56(7):972-4. doi: 10.1212/wnl.56.7.972.
The objective of this study was to use high-resolution MRI techniques to determine whether children with Down syndrome exhibit decreases in hippocampal and amygdala volumes similar to those demonstrated in recent studies of adults with this condition. When corrected for overall brain volumes, amygdala volumes did not differ between groups but hippocampal volumes were significantly smaller in the Down syndrome group. These findings suggest that the hippocampal volume reduction seen in adults with Down syndrome may be primarily due to early developmental differences rather than neurodegenerative changes.
本研究的目的是使用高分辨率磁共振成像（MRI）技术来确定唐氏综合征儿童的海马体和杏仁核体积是否会减小，类似于近期针对患有这种疾病的成年人的研究所显示的情况。在校正全脑体积后，两组之间的杏仁核体积没有差异，但唐氏综合征组的海马体体积明显较小。这些发现表明，唐氏综合征成年人中出现的海马体体积减小可能主要是由于早期发育差异，而非神经退行性变化。
