Hyun I Y, Kwan J, Park K S, Lee W H
Department of Nuclear Medicine, Inha University College of Medicine, Incheon, Korea.
J Nucl Cardiol. 2001 Mar-Apr;8(2):182-7. doi: 10.1067/mnc.2001.112753.
We compared the reproducibility of thallium 201 and technetium 99m sestamibi (MIBI) gated single photon emission computed tomography (SPECT) measurement of myocardial function using the Germano algorithm (J Nucl Med 1995;36:2138-47).
Gated SPECT acquisition was repeated in the same position in 30 patients who received Tl-201 and in 26 who received Tc-99m-MIBI. The quantification of end-diastolic volume (EDV), end-systolic volume (ESV), and ejection fraction (EF) on Tl-201 and Tc-99m-MIBI gated SPECT was processed independently with Cedars-Sinai QGS (Quantitative Gated SPECT) software. The reproducibility of the measurement of ventricular function on Tl-201 gated SPECT was compared with that of Tc-99m-MIBI gated SPECT. Correlation between the 2 measurements for volumes and EF was excellent for the repeated gated SPECT studies of Tl-201 (r = 0.928 to 0.986, P <.05) and Tc-99m-MIBI (r = 0.979 to 0.997, P <.05). However, Bland-Altman analysis revealed the 95% limits of agreement (2 SDs) for volumes and EF were narrower by repeated Tc-99m-MIBI gated SPECT (EDV 14.1 mL, ESV 9.4 mL, EF 5.5%) than by repeated Tl-201 gated SPECT (EDV 24.1 mL, ESV 18.6 mL, EF 10.3%). The root-mean-square values of the coefficient of variation for volumes and EF were smaller by repeated Tc-99m-MIBI gated SPECT (EDV 2.1 mL, ESV 2.7 mL, EF 2.3%) than by repeated Tl-201 gated SPECT (EDV 3.2 mL, ESV 3.5 mL, EF 5.2%).
QGS provides an excellent correlation between repeated gated SPECT with Tl-201 and Tc-99m-MIBI. However, Tc-99m-MIBI provides more reproducible volumes and EF than Tl-201. Tc-99m-MIBI gated SPECT is the preferable method for the clinical monitoring of ventricular function.
我们使用日耳曼诺算法（《核医学杂志》1995年；36:2138 - 2147）比较了铊201和锝99m甲氧基异丁基异腈（MIBI）门控单光子发射计算机断层扫描（SPECT）测量心肌功能的可重复性。
对30例接受铊201检查的患者和26例接受锝99m - MIBI检查的患者在相同位置重复进行门控SPECT采集。使用雪松西奈QGS（定量门控SPECT）软件独立处理铊201和锝99m - MIBI门控SPECT上的舒张末期容积（EDV）、收缩末期容积（ESV）和射血分数（EF）的定量分析。将铊201门控SPECT上心室功能测量的可重复性与锝99m - MIBI门控SPECT的可重复性进行比较。对于铊201（r = 0.928至0.986，P <.05）和锝99m - MIBI（r = 0.979至0.997，P <.05）的重复门控SPECT研究，两次测量的容积和EF之间的相关性极佳。然而，布兰德 - 奥特曼分析显示，重复锝99m - MIBI门控SPECT时容积和EF的95%一致性界限（2个标准差）比重复铊201门控SPECT时更窄（EDV为14.1 mL，ESV为9.4 mL，EF为5.5%），而重复铊201门控SPECT时分别为（EDV为24.1 mL，ESV为18.6 mL，EF为10.3%）。重复锝99m - MIBI门控SPECT时容积和EF的变异系数的均方根值比重复铊201门控SPECT时更小（EDV为2.1 mL，ESV为2.7 mL，EF为2.3%），而重复铊201门控SPECT时分别为（EDV为3.2 mL，ESV为3.5 mL，EF为5.2%）。
QGS在铊201和锝99m - MIBI重复门控SPECT之间提供了极佳的相关性。然而，锝99m - MIBI比铊201提供了更具可重复性的容积和EF。锝99m - MIBI门控SPECT是心室功能临床监测的首选方法。
