Suaning G J, Lovell N H
Graduate School of Biomedical Engineering, Department of Ophthalmology, University of New South Wales, Sydney, Australia.
IEEE Trans Biomed Eng. 2001 Feb;48(2):248-60. doi: 10.1109/10.909646.
100-channel neurostimulation circuit comprising a complementary metal oxide semiconductor (CMOS), application-specific integrated circuit (ASIC) has been designed, constructed and tested. The ASIC forms a significant milestone and an integral component of a 100-electrode neurostimulation system being developed by the authors. The system comprises an externally worn transmitter and a body implantable stimulator. The purpose of the system is to communicate both data and power across tissue via radio-frequency (RF) telemetry such that externally programmable, constant current, charge balanced, biphasic stimuli may be delivered to neural tissue at 100 unique sites. An intrinsic reverse telemetry feature of the ASIC has been designed such that information pertaining to the device function, reconstruction of the stimulation voltage waveform, and the measurement of impedance may be obtained through noninvasive means. To compensate for the paucity of data pertaining to the stimulation thresholds necessary in evoking a physiological response, the ASIC has been designed with scaleable current output. The ASIC has been designed primarily as a treatment of degenerative disorders of the retina whereby the 100 channels are to be utilized in the delivery of a pattern of stimuli of varying intensity and or duty cycle to the surviving neural tissue of the retina. However, it is conceivable that other fields of neurostimulation such as cochlear prosthetics and functional electronic stimulation may benefit from the employment of the system.
已经设计、构建并测试了一种包含互补金属氧化物半导体（CMOS）的100通道神经刺激电路，即专用集成电路（ASIC）。该ASIC构成了作者正在开发的100电极神经刺激系统的一个重要里程碑和不可或缺的组成部分。该系统包括一个外部佩戴的发射器和一个可植入体内的刺激器。该系统的目的是通过射频（RF）遥测在组织中传输数据和电力，以便能够在100个不同部位向神经组织提供外部可编程的、恒流、电荷平衡的双相刺激。ASIC设计了一种固有的反向遥测功能，通过非侵入性手段获取与设备功能、刺激电压波形重建以及阻抗测量相关的信息。为了弥补与引发生理反应所需刺激阈值相关数据的不足，ASIC设计了可缩放电流输出。ASIC主要设计用于治疗视网膜退行性疾病，其中100个通道将用于向视网膜存活的神经组织传递不同强度和/或占空比的刺激模式。然而，可以想象，其他神经刺激领域，如人工耳蜗和功能性电刺激，可能会受益于该系统的应用。
