Le Pendu J, Marionneau S, Cailleau-Thomas A, Rocher J, Le Moullac-Vaidye B, Clément M
INSERM U419, Institute of Biology, Nantes, France.
APMIS. 2001 Jan;109(1):9-31. doi: 10.1111/j.1600-0463.2001.tb00011.x.
Antigens of the ABH and Lewis histo-blood group family can be found on many normal cells, mainly of epithelial type. In carcinomas, altered expression of the various carbohydrate epitopes of this family occur, and are often strongly associated with either a good or bad prognosis. A review of the available data on these tumor-associated markers, their biosynthesis and their prognostic value is proposed here. For a long time it has been unclear whether their presence could affect the behavior of carcinoma cells. Recent data, however, indicate that they play biological roles in the course of tumor progression. The presence of sialyl-Le(a) or sialyl-Le(x), which are ligands for selectins, promotes the metastatic process by facilitating interaction with the endothelium of distant organs. The loss of A and B antigens increases cellular motility, while the presence of H epitopes increases resistance to apoptosis by mechanisms that remain to be defined. The Le(y) antigen has procoagulant and angiogenic activities. All these observations are used to present a model that may account for the described associations between the presence or loss of these markers and the outcome of disease. Finally, their potential clinical applications as tumor-associated markers or as targets of immunotherapy are reviewed.
ABH和Lewis组织血型家族的抗原可在许多正常细胞上找到，主要是上皮类型的细胞。在癌症中，该家族各种碳水化合物表位的表达会发生改变，并且常常与预后好坏密切相关。本文对这些肿瘤相关标志物的现有数据、其生物合成及其预后价值进行综述。长期以来，尚不清楚它们的存在是否会影响癌细胞的行为。然而，最近的数据表明它们在肿瘤进展过程中发挥生物学作用。唾液酸化Le(a)或唾液酸化Le(x)作为选择素的配体，通过促进与远处器官内皮的相互作用来促进转移过程。A和B抗原的缺失会增加细胞运动性，而H表位的存在则通过尚待确定的机制增加对细胞凋亡的抗性。Le(y)抗原具有促凝血和血管生成活性。所有这些观察结果被用于提出一个模型，该模型可能解释所描述的这些标志物的存在或缺失与疾病结局之间的关联。最后，对它们作为肿瘤相关标志物或免疫治疗靶点的潜在临床应用进行了综述。
