Abhyankar S, Salvi V S
Department of Obstetrics and Gynaecology, Seth G. S. Medical College and K. E. M. Hospital, Parel, Mumbai - 400 012, India.
J Postgrad Med. 2000 Jul-Sep;46(3):176-8.
The use of indomethacin in treatment of hydramnios was evaluated.
SUBJECTS & METHODS: Twelve patients with symptomatic hydramnios were treated with indomethacin (2.2- 3.0 mg/kg body weight/day).
The treatment was started at a gestational age of 31.17-/+7.94 weeks and continued for 3.74-/+2.3 weeks. Eleven patients responded to the therapy both subjectively and objectively and pregnancies were prolonged by 4.6-/+3.1 weeks (range 0.1-10 weeks). Five women had term deliveries. Six patients had a favourable perinatal outcome. Four patients who had a known congenital anomaly in the foetus, delivered stillborn babies or had an early neonatal death. One patient who did not follow up after commencing therapy delivered a full-term stillbirth. One patient delivered within 1 day of starting therapy. Indomethacin therapy caused no maternal complications.
Indomethacin was effective in the management of hydramnios and preventing it's complications.
评估吲哚美辛在羊水过多治疗中的应用。
12例有症状的羊水过多患者接受吲哚美辛治疗（2.2 - 3.0毫克/千克体重/天）。
治疗开始时的孕周为31.17±7.94周，持续3.74±2.3周。11例患者在主观和客观上对治疗有反应，孕周延长了4.6±3.1周（范围0.1 - 10周）。5名女性足月分娩。6例患者围产期结局良好。4例已知胎儿有先天性异常的患者，分娩出死产儿或早期新生儿死亡。1例开始治疗后未随访的患者分娩出足月死产儿。1例在开始治疗1天内分娩。吲哚美辛治疗未引起母体并发症。
吲哚美辛在羊水过多的管理及预防其并发症方面有效。
