Mamopoulos M, Assimakopoulos E, Reece E A, Andreou A, Zheng X Z, Mantalenakis S
First Department of Obstetrics and Gynecology, Aristotelian University of Thessaloniki, Greece.
Am J Obstet Gynecol. 1990 May;162(5):1225-9. doi: 10.1016/0002-9378(90)90023-z.
Fifteen patients with polyhydramnios and clinical symptoms related to excess amniotic fluid volume were treated with indomethacin therapy that was started at a mean gestational age of 27.4 +/- 2.79 weeks and discontinued at a mean gestational age of 32.9 +/- 1.83 weeks. Patients were treated with 2.0 to 2.2 mg of indomethacin per kilogram of body weight per day, either orally or by rectal suppositories. No therapy was administered after 35 weeks, and the duration of therapy was no longer than 4 weeks. The majority of fluid reduction occurred within the first week of treatment. Subsequently, a smaller but steady reduction of fluid was observed. All patients were delivered after 38 weeks with a mean birth weight of 3543 +/- 586.3 gm. Examinations of newborns at birth and follow-up at 3 months, 6 months, and 1 year revealed no adverse effects of indomethacin administration.
15例羊水过多且有与羊水量过多相关临床症状的患者接受了吲哚美辛治疗，治疗始于平均孕龄27.4±2.79周，于平均孕龄32.9±1.83周停药。患者每天按每千克体重2.0至2.2毫克的剂量接受吲哚美辛治疗，给药途径为口服或直肠栓剂。35周后不再进行治疗，治疗持续时间不超过4周。大部分羊水减少发生在治疗的第一周内。随后，观察到羊水有较小但稳定的减少。所有患者均在38周后分娩，平均出生体重为3543±586.3克。新生儿出生时的检查以及3个月、6个月和1岁时的随访显示，使用吲哚美辛没有不良反应。
