Nenseter M S, Østerud B, Larsen T, Strøm E, Bergei C, Hewitt S, Holven K B, Hagve T A, Mjøs S A, Solvang M, Pettersen J, Opstvedt J, Ose L
Lipid Clinic, University of Oslo, Rikshospitalet, 0027 Oslo, Norway.
Nutr Metab Cardiovasc Dis. 2000 Dec;10(6):323-30.
Numerous studies suggest an association between high intake of fatty fish and reduced risk of coronary heart disease. Very long-chain omega-3 fatty acids are thought to be responsible for the benefits observed, though other fatty fish components may act in concert with them. Norwegian fish powder is a dry herring product that contains essential amino acids, marine omega-3 fatty acids, vitamins and minerals. The aim of the present study was to determine whether it has beneficial effects on risk factors for coronary heart disease in man.
A single center, randomized, double-blind, parallel-treatment study was carried out for 12 weeks. Subjects with primary hypercholesterolemia were randomly allocated to 10 g fish powder or placebo (20 tablets/day). Participants were instructed to follow National Cholesterol Education Program (NCEP) Step I Diet during a 4-week diet run-in phase and during the study. Concentrations of lipids, lipoproteins, hemostatic variables and endothelial cell markers were determined before and after supplementation. Our data showed that the fish powder supplement was well tolerated. A significant decrease and increase respectively were observed in plasma alpha-linolenic acid (p = 0.03) and docosahexaenoic acid (DHA) (p = 0.03). Concentrations of lipids, lipoproteins, homocysteine, factor VII, fibrinogen, tissue plasminogen activator (tPA), plasminogen activator inhibitor (PAI)-1, soluble intercellular adhesion molecule (ICAM)-1, P-selectin and interleukin (IL)-8 were not beneficially affected.
Fish powder supplementation does not seem an effective approach to improve risk factors for coronary heart disease in hypercholesterolemic subjects following the NCEP Step I Diet.
大量研究表明，大量摄入富含脂肪的鱼类与冠心病风险降低之间存在关联。超长链ω-3脂肪酸被认为是观察到的这些益处的原因，不过其他富含脂肪的鱼类成分可能与它们协同发挥作用。挪威鱼粉是一种干鲱鱼产品，含有必需氨基酸、海洋ω-3脂肪酸、维生素和矿物质。本研究的目的是确定其对人类冠心病危险因素是否具有有益作用。
进行了一项为期12周的单中心、随机、双盲、平行治疗研究。原发性高胆固醇血症患者被随机分配至服用10克鱼粉或安慰剂组（每日20片）。在为期4周的饮食导入期及研究期间，参与者被要求遵循美国国家胆固醇教育计划（NCEP）第一步饮食方案。在补充前后测定脂质、脂蛋白、止血变量和内皮细胞标志物的浓度。我们的数据表明，鱼粉补充剂耐受性良好。血浆α-亚麻酸（p = 0.03）和二十二碳六烯酸（DHA）（p = 0.03）分别出现显著下降和上升。脂质、脂蛋白、同型半胱氨酸、因子VII、纤维蛋白原、组织型纤溶酶原激活剂（tPA）、纤溶酶原激活剂抑制剂（PAI）-1、可溶性细胞间黏附分子（ICAM）-1、P-选择素和白细胞介素（IL）-8的浓度未受到有益影响。
对于遵循NCEP第一步饮食方案的高胆固醇血症患者，补充鱼粉似乎不是改善冠心病危险因素的有效方法。
