Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Number 74 Zhongshan Road 2, 510080 Guangzhou, Guangdong, China.
Nutr J. 2013 Nov 7;12(1):144. doi: 10.1186/1475-2891-12-144.
Dietary patterns are associated with plasma total homocysteine (tHcy) concentrations in healthy populations, but the associations between dietary protein and tHcy, total cysteine (tCys) in high risk populations are unclear. We therefore examined the association between dietary protein and tHcy and tCys concentrations in coronary angiographic subjects.
We conducted a cross-sectional study of 1015 Chinese patients who underwent coronary angiography (40-85 y old). With the use of food-frequency questionnaires, we divided the total protein intakes into high animal-protein and high plant-protein diets. Circulating concentrations of tHcy and tCys were simultaneously measured by high-performance liquid chromatography with fluorescence detection.
We found that high animal-protein diet was positively associated with hyperhomocysteinemia after adjustment for potential confounders, with the subjects in the highest quartile of intake having the greatest increase in risk (OR: 4.14, 95% CI: 2.67-6.43), whereas high plant-protein diet was inversely related to hyperhomocysteinemia, with a higher intake being protective. Compared with the first quartile of intake, the adjusted OR was 0.59 (95% CI: 0.38-0.91) for the fourth quartile. The total protein intake was positively associated with the risk of hypercysteinemia and the participants in highest quartile had significant OR of 1.69 (95% CI: 1.02-2.87) compared with those in lowest quartile. In multivariate linear regression analyses, high animal-protein and total-protein intakes were positively associated with plasma tHcy and tCys concentrations. The plant-protein intake was a negative determinant of plasma tHcy concentrations.
High animal-protein diet was positively associated with high tHcy concentrations, whereas high plant-protein diet was inversely associated with tHcy concentrations. Furthermore the total protein intake was strongly related to tCys concentrations.
在健康人群中，饮食模式与血浆总同型半胱氨酸（tHcy）浓度有关，但高风险人群中饮食蛋白与 tHcy、总半胱氨酸（tCys）之间的关系尚不清楚。因此，我们研究了冠状动脉造影患者饮食蛋白与 tHcy 和 tCys 浓度之间的关系。
我们对 1015 例接受冠状动脉造影的中国患者（40-85 岁）进行了一项横断面研究。使用食物频率问卷，我们将总蛋白摄入量分为高动物蛋白和高植物蛋白饮食。通过高效液相色谱法-荧光检测同时测量循环 tHcy 和 tCys 浓度。
我们发现，在调整潜在混杂因素后，高动物蛋白饮食与高同型半胱氨酸血症呈正相关，摄入量最高四分位的患者风险增加最大（OR：4.14，95%CI：2.67-6.43），而高植物蛋白饮食与高同型半胱氨酸血症呈负相关，摄入较高量具有保护作用。与摄入量最低的四分位相比，第四四分位的调整 OR 为 0.59（95%CI：0.38-0.91）。总蛋白摄入量与高半胱氨酸血症风险呈正相关，与最低四分位相比，最高四分位的参与者的 OR 显著为 1.69（95%CI：1.02-2.87）。在多元线性回归分析中，高动物蛋白和总蛋白摄入量与血浆 tHcy 和 tCys 浓度呈正相关。植物蛋白摄入量是血浆 tHcy 浓度的负决定因素。
高动物蛋白饮食与高 tHcy 浓度呈正相关，而高植物蛋白饮食与 tHcy 浓度呈负相关。此外，总蛋白摄入量与 tCys 浓度密切相关。
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