Wynder E L, Rose D P, Cohen L A
Division of Epidemiology, American Health Foundation, New York, NY 10017, USA.
Nutr Cancer. 1994;22(1):1-10. doi: 10.1080/01635589409514327.
In this review, we consider the evidence from geographic and metabolic epidemiology and laboratory studies with human prostate cancer cell lines and animal models that emphasizes the need for the development and implementation of a dietary intervention trial in prostate cancer patients. It is concluded that such a trial should include a reduction in total fat consumption to 15% of total calories and supplementation of the diet with selenium, vitamin E, and a soya product. The low-fat intervention would provide an appropriate reduction in the intake of any specifically targeted dietary fatty acid, such as linoleic acid or alpha-linolenic acid.
在本综述中，我们审视了来自地理和代谢流行病学以及对人类前列腺癌细胞系和动物模型的实验室研究的证据，这些证据强调了在前列腺癌患者中开展并实施饮食干预试验的必要性。得出的结论是，这样一项试验应包括将总脂肪摄入量减少至总热量的15%，并在饮食中补充硒、维生素E和一种豆制品。低脂干预将适度减少任何特定目标膳食脂肪酸（如亚油酸或α-亚麻酸）的摄入量。
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