在α-生育酚、β-胡萝卜素癌症预防研究中基线维生素E、硒与前列腺癌之间的关联。

The association between baseline vitamin E, selenium, and prostate cancer in the alpha-tocopherol, beta-carotene cancer prevention study.

作者信息

Hartman T J, Albanes D, Pietinen P, Hartman A M, Rautalahti M, Tangrea J A, Taylor P R

机构信息

Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, Maryland 20892-7326, USA.

出版信息

Cancer Epidemiol Biomarkers Prev. 1998 Apr;7(4):335-40.

PMID:9568790

Abstract

The association between prostate cancer and baseline vitamin E and selenium was evaluated in the trial-based cohort of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (n = 29,133). During up to 9 years of follow-up, 317 men developed incident prostate cancer. Multivariate Cox proportional hazards models that adjusted for intervention group, benign prostatic hyperplasia, age, smoking, and urban residence were used to evaluate associations between prostate cancer and exposures of interest. There were no significant associations between baseline serum alpha-tocopherol, dietary vitamin E, or selenium and prostate cancer overall. The associations between prostate cancer and vitamin E and some of the baseline dietary tocopherols differed significantly by alpha-tocopherol intervention status, with the suggestion of a protective effect for total vitamin E among those who received the alpha-tocopherol intervention (relative risk was 1.00, 0.68, 0.80, and 0.52 for increasing quartiles; P = 0.07).

摘要

在α-生育酚、β-胡萝卜素癌症预防研究的基于试验的队列（n = 29,133）中，评估了前列腺癌与基线维生素E和硒之间的关联。在长达9年的随访期间，317名男性患了前列腺癌。使用多变量Cox比例风险模型，对干预组、良性前列腺增生、年龄、吸烟和城市居住情况进行了调整，以评估前列腺癌与感兴趣的暴露因素之间的关联。总体而言，基线血清α-生育酚、膳食维生素E或硒与前列腺癌之间没有显著关联。前列腺癌与维生素E以及一些基线膳食生育酚之间的关联因α-生育酚干预状态而有显著差异，对于接受α-生育酚干预的人群，总维生素E有保护作用（四分位数增加时相对风险分别为1.00、0.68、0.80和0.52；P = 0.07）。