Hahn C J, Evans G W
Am J Physiol. 1975 Apr;228(4):1020-3. doi: 10.1152/ajplegacy.1975.228.4.1020.
The effects of zinc deficiency on the whole-body absorption and intestinal content of Zn, Cd, Cu, Co, Fe, Mn, and Cr were determined in the rat 1 h after oral administration of the isotopes. Both the absorption and intestinal content of Zn and Cr were increased in zinc-deficient rats, and the intestinal content of Feand Co was also increased in the zinc-deficient animals. Zinc administered orally with Cr decreased both absorption and intestinal content of the isotope in zinc-deficient rats. Chromium administered orally with Zn decreased intestinal content and absorption of Zn in zinc-deficient rats. Fractionation of mucosal supernatants by gel filtration showed that both zinc and chromium eluted in the same low molecular weight fraction. The elution patterns of zinc and cadmium from that of zinc-supplemented animals. These experiments provide some insight into the specificity of the zinc absorption pathway and present some explanations for the interaction or lack of interaction among trace elements.
在大鼠口服同位素1小时后，测定了缺锌对锌、镉、铜、钴、铁、锰和铬的全身吸收及肠道含量的影响。缺锌大鼠体内锌和铬的吸收及肠道含量均增加，缺铁和钴的动物肠道含量也增加。在缺锌大鼠中，口服锌与铬会降低该同位素的吸收及肠道含量。口服锌与铬会降低缺锌大鼠肠道中锌的含量及吸收。通过凝胶过滤对黏膜上清液进行分级分离显示，锌和铬均在相同的低分子量级分中洗脱。锌和镉的洗脱模式与补锌动物的不同。这些实验为锌吸收途径的特异性提供了一些见解，并对微量元素之间的相互作用或缺乏相互作用给出了一些解释。
