Mirmirani P, Hessol N A, Maurer T A, Berger T G, Nguyen P, Khalsa A, Gurtman A, Micci S, Young M, Holman S, Gange S J, Greenblatt R M
WIHS Collaborative Study Group, University of California, San Francisco 94143-0316, USA.
J Am Acad Dermatol. 2001 May;44(5):785-8. doi: 10.1067/mjd.2001.112350.
We attempted to determine the prevalence and predictors of skin disease in a cohort of women with and at risk for HIV infection.
We analyzed baseline data from a multicenter longitudinal study of HIV infection in women.
A total of 2018 HIV-infected women and 557 HIV-uninfected women were included in this analysis. Skin abnormalities were reported more frequently among HIV-infected than uninfected women (63% vs 44%, respectively; odds ratio [OR] 2.10; 95% confidence interval [95% CI], 1.74-2.54). Infected women were also more likely to have more than 2 skin diagnoses (OR, 3.27; 95% CI, 1.31-8.16). Folliculitis, seborrheic dermatitis, herpes zoster, and onychomycosis were more common among HIV-infected women (P < .05). Independent predictors of abnormal findings on skin examination in the infected women were African American race (OR, 1.38; 95% CI, 1.07-1.77), injection drug use (OR, 2.74; 95% CI, 2.11-3.57), CD4(+) count less than 50 (OR, 1.68; 95% CI, 1.17-2.42), and high viral loads (100,000-499,999 = OR, 1.77; 95% CI, 1.32-2.37; > 499,999 = OR, 2.15; 95% CI, 1.42-3.27).
HIV infection was associated with a greater number of skin abnormalities and with specific dermatologic diagnoses. Skin abnormalities were also more common among women with CD4(+) cell depletion or higher viral load.
我们试图确定一组感染HIV以及有感染HIV风险的女性中皮肤病的患病率及预测因素。
我们分析了一项关于女性HIV感染的多中心纵向研究的基线数据。
本分析共纳入了2018名感染HIV的女性和557名未感染HIV的女性。报告显示，感染HIV的女性比未感染的女性皮肤异常更为常见（分别为63%和44%；优势比[OR]2.10；95%置信区间[95%CI]，1.74 - 2.54）。感染HIV的女性也更有可能有超过2种皮肤诊断结果（OR，3.27；95%CI，1.31 - 8.16）。毛囊 炎、脂溢性皮炎、带状疱疹和甲癣在感染HIV的女性中更为常见（P < 0.05）。感染女性皮肤检查异常结果的独立预测因素包括非裔美国人种族（OR，1.38；95%CI，1.07 - 1.77）、注射吸毒（OR，2.74；95%CI，2.11 - 3.57）、CD4(+)细胞计数低于50（OR，1.68；95%CI，1.17 - 2.42）以及高病毒载量（100,000 - 499,999 = OR，1.77；95%CI，1.32 - 2.37；> 499,999 = OR，2.15；95%CI，1.42 - 3.27）。
HIV感染与更多的皮肤异常以及特定的皮肤病诊断相关。皮肤异常在CD4(+)细胞耗竭或病毒载量较高的女性中也更为常见。
