Wolinsky H, Goldfischer S, Katz D, Markle R, Gidez L, Wassertheil-Smoller S, Coltoff-Schiller B
Circ Res. 1979 Oct;45(4):546-53. doi: 10.1161/01.res.45.4.546.
It is possible that one of the consequences of regular physical activity could be a change of vascular metabolism. We studied the effects of regular swimming activity on specific activities of aortic hydrolases of male rats. Enzymes included: neutral alpha-glucosidase and lysosomal beta-galactosidase, N-acetyl-beta-glucosaminidase, cathepsin C, acid alpha-glucosidase, and acid cholesteryl esterase. After 8 or 16 weeks of a 1-hour/day swimming protocol, specific activities of four of the six aortic enzymes studied were increased over control levels, increases ranging from 7 to more than 42%. Acid cholesteryl esterase was one of the enzymes most affected by the exercise, increasing 25-30% above control levels. An 8-week sedentary period, after 8 weeks of a swimming regimen, resulted in return of the activity of acid cholesteryl esterase, but not those of the other hydrolases, to control levels. Decreases in body weight, blood pressure, and serum lipid levels also occurred in the swimming rats. Weight reduction per se was excluded as an explanation for the increases in aortic enzymes or decrease in serum cholesterol found with swimming. These findings show that regular physical activity is yet another factor with discrete and significant effects on the catabolic activity of vascular tissue.
定期进行体育活动的后果之一可能是血管代谢的改变。我们研究了定期游泳活动对雄性大鼠主动脉水解酶特定活性的影响。所研究的酶包括：中性α-葡萄糖苷酶、溶酶体β-半乳糖苷酶、N-乙酰-β-葡萄糖胺酶、组织蛋白酶C、酸性α-葡萄糖苷酶和酸性胆固醇酯酶。在每天进行1小时游泳训练8周或16周后，所研究的六种主动脉酶中有四种的特定活性高于对照水平，增幅在7%至42%以上。酸性胆固醇酯酶是受运动影响最大的酶之一，比对照水平增加了25%-30%。在进行8周游泳训练后，8周的久坐期导致酸性胆固醇酯酶的活性恢复到对照水平，但其他水解酶的活性未恢复。游泳大鼠的体重、血压和血脂水平也有所下降。体重减轻本身被排除为游泳导致主动脉酶增加或血清胆固醇降低的解释。这些发现表明，定期体育活动是对血管组织分解代谢活性有离散且显著影响的又一个因素。
