Lai T J, Guo Y L, Guo N W, Hsu C C
Department of Psychiatry, Chung-Shan Medical and Dental College, Taichung, Taiwan.
Br J Psychiatry Suppl. 2001 Apr;40:s49-52. doi: 10.1192/bjp.178.40.s49.
From 1978 to 1979, a group of people in Taiwan were exposed to high levels of heat-degraded polychlorinated biphenyls (PCBs) owing to accidental ingestion of contaminated rice oil. Children born to mothers following the exposure ('Yucheng' children) were known to have hyperpigmented skin and other dysmorphology after birth.
To determine the effect of prenatal exposure to PCBs on cognitive development in Yucheng children.
One hundred and eighteen Yucheng children prenatally exposed to PCBs and degradation products, and community-matched control children who were exposed to background levels only, were followed from 1985 to 1998. The Bayley Scale for Infant Development, Chinese version of the Stanford-Binet IQ Test, Raven's Coloured Progressive Matrices and Raven's Standardised Progressive Matrices were used to assess the cognitive development of these children.
The Yucheng children scored lower than control children on each of these methods of measurement between the ages of 2 and 12 years.
Prenatal exposure to PCBs and their derivatives has long-term adverse effects on cognitive development in humans.
1978年至1979年期间，台湾一群人因意外摄入受污染的米糠油而接触到高浓度的热降解多氯联苯（PCBs）。接触后出生的婴儿（“油症”儿童）出生后皮肤色素沉着过度且有其他畸形。
确定产前接触多氯联苯对“油症”儿童认知发育的影响。
1985年至1998年，对118名产前接触多氯联苯及其降解产物的“油症”儿童以及仅接触背景水平污染物的社区匹配对照儿童进行跟踪研究。使用贝利婴儿发育量表、中文版斯坦福-比奈智力量表、瑞文彩色渐进矩阵测验和瑞文标准渐进矩阵测验来评估这些儿童的认知发育情况。
在2至12岁的各个测量方法中，“油症”儿童的得分均低于对照儿童。
产前接触多氯联苯及其衍生物对人类认知发育有长期不良影响。
