Lai Te-Jen, Liu Xianchen, Guo Yueliang Leon, Guo Nai-Wen, Yu Mei-Lin, Hsu Chen-Chin, Rogan Walter J
Department of Psychiatry, Chung Shan Medical University, Taichung, Taiwan.
Arch Gen Psychiatry. 2002 Nov;59(11):1061-6. doi: 10.1001/archpsyc.59.11.1061.
In 1978, about 2000 persons in Taiwan were poisoned when their cooking oil was contaminated during manufacture with heat-degraded polychlorinated biphenyls, which are toxic, very widespread pollutant chemicals. The chemicals cannot be metabolized or excreted, and 8 of the first 39 children born to affected women died. When examined in 1985, 117 surviving children were found to have ectodermal defects, developmental delay, and disordered behavior. We have continued to observe the children.
From 1992 through 1995, 118 children born between 1978 and 1985 (during or after their mothers' exposure) and 118 matched neighborhood control children had cognitive function measured yearly with the Wechsler Intelligence Scale for Children-Revised and behavioral problems measured with the Achenbach Child Behavior Checklist and the Rutter Child Behavior Scale A.
The exposed children scored 3 points (P =.05) lower than control children for IQ; 3 points (P =.002) higher on the Child Behavior Checklist (an effect size similar to the sex difference); and 6 points (P<.001) higher on the Rutter scale (3 times the sex difference). Birth year x exposure interactions, testing whether children born long after the exposure were as affected as those born soon after, were small and not significant. Age x exposure interactions, testing whether the children improved relative to control children as they got older, were significant only for the Rutter scale.
Prenatal exposure to these compounds produces long-lasting cognitive and behavioral damage, but there is some evidence of recovery.
1978年，台湾约2000人因食用油在生产过程中被热降解多氯联苯污染而中毒，多氯联苯是有毒且广泛存在的污染性化学物质。这些化学物质无法被代谢或排出体外，受影响女性所生的前39名儿童中有8名死亡。1985年检查时，发现117名存活儿童有外胚层缺陷、发育迟缓及行为紊乱。我们一直在观察这些儿童。
1992年至1995年期间，对1978年至1985年出生（其母亲接触污染食用油期间或之后）的118名儿童以及118名相匹配的社区对照儿童，每年用韦氏儿童智力量表修订版测量认知功能，并用阿肯巴克儿童行为量表和拉特儿童行为量表A测量行为问题。
暴露组儿童的智商得分比对照组儿童低3分（P = 0.05）；在儿童行为量表上得分高3分（P = 0.002）（效应大小与性别差异相似）；在拉特量表上得分高6分（P<0.001）（是性别差异的3倍）。出生年份×暴露的交互作用，即检验暴露后很久出生的儿童是否与暴露后不久出生的儿童受影响程度相同，作用较小且无统计学意义。年龄×暴露的交互作用，即检验儿童随着年龄增长相对于对照儿童是否有所改善，仅在拉特量表上有统计学意义。
产前接触这些化合物会造成持久的认知和行为损害，但有一些恢复的证据。
