Chen Y C, Guo Y L, Hsu C C
Department of Psychiatry, National Cheng Kung University Medical College, Tainan, Taiwan, R.O.C.
J Formos Med Assoc. 1992 Jul;91(7):704-7.
An intoxication episode resulting from rice-bran oil (Yu-Cheng) contaminated with polychlorinated biphenyls (PCBs) occurred in Taiwan from 1978 to 1979. After that episode, the authors found 15 Yu-Cheng children who were born to intoxicated mothers after their documented consumption of PCB-contaminated oil; these children had older siblings, born before PCB exposure, without prenatal PCB exposure. The cognitive development of these Yu-Cheng children and the youngest of their elder siblings were assessed annually from 1985 to 1990 using the Chinese version of the Wechsler Intelligence Scale for Children, Revised Version (WISC-R) for those over six years of age. Compared with their elder siblings, the Yu-Cheng children scored significantly lower (p < 0.05) on the verbal intelligence quotient, by 6.8-16.1 points; on performance IQ by 10.2-18.4 points; and on full-scale IQ by 8.9-18.5 points, during the six measurements performed from 1985 to 1990. The differences in WISC-R IQ scores between the two groups have remained unchanged during these six years of follow-up.
1978年至1979年期间，台湾发生了一起因食用被多氯联苯（PCBs）污染的米糠油（油症）而导致的中毒事件。该事件发生后，作者发现有15名油症儿童，其母亲在食用记录显示被PCBs污染的油后受孕并生下他们；这些儿童有在PCBs暴露之前出生的哥哥姐姐，他们未在出生前接触过PCBs。1985年至1990年期间，每年使用中文版韦氏儿童智力量表修订版（WISC-R）对6岁以上的这些油症儿童及其年龄最小的哥哥姐姐进行认知发展评估。与他们的哥哥姐姐相比，在1985年至1990年进行的6次测量中，油症儿童在言语智商上显著较低（p < 0.05），低6.8 - 16.1分；在操作智商上低10.2 - 18.4分；在总智商上低8.9 - 18.5分。在这六年的随访期间，两组之间WISC-R智商分数的差异保持不变。
