Talley N J, Howell S, Poulton R
Department of Medicine, University of Sydney, Nepean Hospital, Penrith, NSW, Australia.
Am J Gastroenterol. 2001 Apr;96(4):1072-9. doi: 10.1111/j.1572-0241.2001.03741.x.
Psychiatric morbidity is high among patients who present to referral centers with irritable bowel syndrome (IBS). However, few studies have investigated the relationship between psychiatric disturbance and IBS in community samples. We hypothesized that psychiatric disorders are linked to IBS in the general community, but this is influenced by the criteria used to establish a diagnosis of IBS.
The data were collected from a birth cohort born in Dunedin (New Zealand) between April 1972 and March 1973. This cohort consisted of 1037 members (52% male), who were assessed at ages 3, 5, 7, 9, 11, 13, 15, 18, 21, and 26 yr. GI symptoms were recorded at age 26 yr, using an abbreviated version of the Bowel Symptom Questionnaire; psychiatric history was obtained at ages 18 and 21 yr, using a modified version of the Diagnostic Interview Schedule.
The prevalence of IBS was 12.7% according to the Manning criteria and 4.3% according to the Rome II criteria. The IBS was not significantly related to a diagnostic history for psychiatric illness overall, nor to a history of anxiety disorders, depressive disorders, and substance dependence. These results were independent of the IBS criteria used; there was no association between psychiatric history and IBS when IBS was defined according to the Manning criteria (p = 0.11 to 0.98) or the Rome criteria (p = 0.18 to 0.92): Rome and Manning criteria subjects did not significantly differ from each other in terms of psychiatric history (p = 0.16 to 0.89).
In a cohort of young adults with IBS from New Zealand, IBS appears to not be related to psychiatric disorders.
在因肠易激综合征（IBS）前往转诊中心就诊的患者中，精神疾病的发病率很高。然而，很少有研究调查社区样本中精神障碍与IBS之间的关系。我们假设精神疾病与普通社区中的IBS有关，但这受到用于确立IBS诊断的标准的影响。
数据收集自1972年4月至1973年3月在达尼丁（新西兰）出生的一个出生队列。该队列由1037名成员组成（52%为男性），他们在3岁、5岁、7岁、9岁、11岁、13岁、15岁、18岁、21岁和26岁时接受了评估。在26岁时使用简化版的肠道症状问卷记录胃肠道症状；在18岁和21岁时使用改良版的诊断访谈表获取精神病史。
根据曼宁标准，IBS的患病率为12.7%，根据罗马II标准为4.3%。总体而言，IBS与精神疾病的诊断史无关，也与焦虑症、抑郁症和物质依赖史无关。这些结果与所使用的IBS标准无关；当根据曼宁标准（p = 0.11至0.98）或罗马标准（p = 0.18至0.92）定义IBS时，精神病史与IBS之间没有关联：在精神病史方面，根据罗马标准和曼宁标准的受试者之间没有显著差异（p = 0.16至0.89）。
在一组来自新西兰的患有IBS的年轻成年人中，IBS似乎与精神疾病无关。
