Masand P S, Kaplan D S, Gupta S, Bhandary A N, Nasra G S, Kline M D, Margo K L
Department of Psychiatry, State University of New York Health Science Center, Syracuse 13210, USA.
J Clin Psychiatry. 1995 Aug;56(8):363-7.
Irritable bowel syndrome (IBS) has been reported in 10% to 22% of adults. Seventy percent to 90% of patients with IBS who seek medical attention have psychiatric comorbidity, most commonly major depression. In contrast, few studies have looked at the prevalence of IBS among psychiatric patients.
Using a semistructured clinical interview to study the prevalence of IBS, we compared 56 patients seeking treatment for major depression in an outpatient setting to an age- and sex-matched control group of patients (N = 40) who were seeking treatment in a general physician's office for other medical illnesses. The control group had no Axis I disorders. IBS was diagnosed according to the criteria of Drossman et al.
Twenty-seven percent (N = 15) of patients with major depression met criteria for IBS in contrast to 2.5% (N = 1) of the control group (p = .0005). Patients with major depression and IBS were more likely to report symptoms of back pain, weakness, heartburn, and nocturnal bowel movements as well as a personal or family history of bowel disease compared with patients with major depression but without IBS.
IBS is fairly common in patients seeking treatment for major depression. Prospective studies should address the question whether treatment of major depression leads to an improvement or resolution of the symptoms of IBS.
据报道，10%至22%的成年人患有肠易激综合征（IBS）。在寻求医疗帮助的IBS患者中，70%至90%患有精神疾病合并症，最常见的是重度抑郁症。相比之下，很少有研究关注精神疾病患者中IBS的患病率。
我们采用半结构化临床访谈来研究IBS的患病率，将56名在门诊寻求重度抑郁症治疗的患者与一个年龄和性别匹配的对照组（N = 40）进行比较，该对照组是在普通内科医生办公室因其他疾病寻求治疗的患者。对照组没有轴I障碍。IBS根据德罗兹曼等人的标准进行诊断。
重度抑郁症患者中有27%（N = 15）符合IBS标准，而对照组为2.5%（N = 1）（p = .0005）。与没有IBS的重度抑郁症患者相比，患有重度抑郁症和IBS的患者更有可能报告背痛、虚弱、烧心、夜间排便症状以及肠道疾病的个人或家族史。
IBS在寻求重度抑郁症治疗的患者中相当常见。前瞻性研究应探讨重度抑郁症的治疗是否会改善或缓解IBS症状这一问题。
