一组大麻纤维加工工人的呼吸道症状、肺功能和细胞表面标志物

Respiratory symptoms, lung function and cell surface markers in a group of hemp fiber processors.

作者信息

Fishwick D, Allan L J, Wright A, Barber C M, Curran A D

机构信息

Health and Safety Laboratory, Broad Lane, Sheffield, UK S3 7HQ.

出版信息

Am J Ind Med. 2001 Apr;39(4):419-25. doi: 10.1002/ajim.1033.

DOI:10.1002/ajim.1033

PMID:11323792

Abstract

BACKGROUND

Hemp dust exposure is associated with byssinosis and accelerated lung loss in longitudinal studies. The immunological changes associated with hemp dust exposure are less well understood.

METHODS

We studied a small group of current male hemp processors with a mean age of 43 years. Questionnaire data, lung function, serial FEV(1) and blood were collected from all workers.

RESULTS

In total, seven workers (64%) complained of at least one respiratory symptom (one with byssinosis). The mean percentage predicted FEV(1) was 91.5, FVC 97.7, PEF 92.1, and FEF(25-75) 79.5. Serial FEV(1) measurements in the two workers with work-related respiratory symptoms revealed a mean change in FEV(1) on the first working day of -12.9%. This contrasted with +6.25% on the last working day. Respective values for the two workers without work-related symptoms were -1.4 and +3.2%.

CONCLUSIONS

Lung function changes and abnormalities in a profile of cell surface activation markers and antibodies were noted to relate to the presence of work-related respiratory symptoms, not seen in the control group.

摘要

背景

在纵向研究中，接触大麻粉尘与棉尘肺和肺功能加速丧失有关。与接触大麻粉尘相关的免疫变化尚不太清楚。

方法

我们研究了一小群当前的男性大麻加工工人，平均年龄为43岁。收集了所有工人的问卷调查数据、肺功能、连续的第一秒用力呼气容积（FEV₁）和血液样本。

结果

共有7名工人（64%）抱怨至少有一种呼吸道症状（1名患有棉尘肺）。预测的FEV₁平均百分比为91.5%，用力肺活量（FVC）为97.7%，呼气峰值流量（PEF）为92.1%，25%至75%肺活量之间的用力呼气流量（FEF₂₅₋₇₅）为79.5%。对两名有工作相关呼吸道症状的工人进行的连续FEV₁测量显示，在第一个工作日FEV₁的平均变化为-12.9%。相比之下，在最后一个工作日为+6.25%。两名无工作相关症状工人的相应数值分别为-1.4%和+3.2%。