Monaghan H, Salter D M, Al-Nafussi A
Department of Pathology, Edinburgh University Medical School, Teviot Place, Edinburgh EH8 9AG, UK.
J Clin Pathol. 2001 May;54(5):404-7. doi: 10.1136/jcp.54.5.404.
AIMS/BACKGROUND: Giant cell tumour of the tendon sheath (GCTTS) is regarded as the most common neoplasm of the hand that can recur after excision. The objective of this study was to review a series of cases in our department and to determine any clinical or pathological features that might predict the likelihood of recurrence.
Clinical data, obtained from pathology request forms and in patient notes, along with the gross and microscopic appearances of 71 cases of GCTTS were evaluated.
Clinical features and pathological features identified were similar to those of previous studies. In comparison with previous studies a higher mitotic count (range, 1-21 mitoses/10 high power fields (HPF); mean, 5/10 HPF) was noted in all cases, irrespective of recurrence and numerous apoptotic bodies (up to 30/10 HPF), mainly formed from osteoclast-like giant cells, were present.
GCTTS is a relatively rare soft tissue tumour of uncertain histiogenesis. Mitotic and apoptotic figures are a common feature and do not indicate clinical behaviour. Complete local excision is the treatment of choice.
目的/背景：腱鞘巨细胞瘤（GCTTS）被认为是手部最常见的肿瘤，切除后可能复发。本研究的目的是回顾我科的一系列病例，并确定任何可能预测复发可能性的临床或病理特征。
评估从病理申请表和住院病历中获得的临床数据，以及71例腱鞘巨细胞瘤的大体和显微镜下表现。
所确定的临床特征和病理特征与先前研究相似。与先前研究相比，所有病例均观察到较高的有丝分裂计数（范围为1 - 21个有丝分裂/10个高倍视野（HPF）；平均为5/10 HPF），无论是否复发，并且存在大量凋亡小体（多达30/10 HPF），主要由破骨细胞样巨细胞形成。
腱鞘巨细胞瘤是一种组织发生不确定的相对罕见的软组织肿瘤。有丝分裂和凋亡图像是常见特征，并不表明临床行为。完整的局部切除是首选治疗方法。
