Tanaka T, Benedek G B
Invest Ophthalmol. 1975 Jun;14(6):449-56.
Using the technique of optical mixing spectroscopy, we have observed the Brownian movement and measured the diffusivity of proteins within whole, intact human and bovine lenses. The magnitude and the temperature dependence of the protein diffusivity in bovine and normal human lenses implies that cold cataract is the result of a first-order phase separation of the protein-water mixture in the lens. The magnitude of the diffusivity of proteins within cataractous human lenses indicates the presence of large aggregates of proteins.
利用光学混合光谱技术，我们观察了完整的人眼和牛眼晶状体中蛋白质的布朗运动并测量了其扩散系数。牛眼晶状体和正常人眼晶状体中蛋白质扩散系数的大小及其对温度的依赖性表明，冷性白内障是晶状体中蛋白质 - 水混合物一级相分离的结果。白内障患者眼晶状体中蛋白质扩散系数的大小表明存在大量蛋白质聚集体。
