Packer S, Lambrecht R M, Merrill J C, Atkins H L, Wolf A P
Invest Ophthalmol. 1975 Jun;14(6):492-4.
The ability of radioactive lead to localize melanomas was studied. The Greene melanoma in the Syrian Golden hamster served as a model for both skin and ocular melanoma. The affinity of heavy metals for neoplasms has been studied but previous reports have been inconsistent as to tumor specificity. For this investigation the radioactive lead (203-Pb,) was studied as the chemical complex 203-Pb-Tris. Significant tumor:nontumor ratios were found in ocular melanoma and the concentration in the lens was minimal. The ratio of per cent uptake per gram of tumor: per cent uptake per gram in control tissue with skin melanoma was 9.4 at 24 hours and for the eye melanoma the ratio was 26.3 at 24 hours. The affinity of 203-Pb-Tris for melanomas appears to be as promising as other compounds presently being evaluated for ocular scintigraphy, namely, labeled quinoline analogs. Therefore, further preclinical evaluation is warranted.
研究了放射性铅定位黑色素瘤的能力。叙利亚金仓鼠身上的格林黑色素瘤用作皮肤和眼部黑色素瘤的模型。人们已经研究了重金属对肿瘤的亲和力，但先前的报告在肿瘤特异性方面并不一致。在本次研究中，放射性铅（²⁰³-Pb）以化学复合物²⁰³-Pb-三羟甲基氨基甲烷（²⁰³-Pb-Tris）的形式进行研究。在眼部黑色素瘤中发现了显著的肿瘤与非肿瘤比例，且晶状体中的浓度最低。皮肤黑色素瘤在24小时时每克肿瘤摄取百分比与每克对照组织摄取百分比的比值为9.4，眼部黑色素瘤在24小时时该比值为26.3。²⁰³-Pb-Tris对黑色素瘤的亲和力似乎与目前正在用于眼部闪烁扫描评估的其他化合物（即标记的喹啉类似物）一样有前景。因此，有必要进行进一步的临床前评估。
