Packer S, Redvanly C, Lambrecht R M, Wolf A P, Atkins H L
Arch Ophthalmol. 1975 Jul;93(7):504-8. doi: 10.1001/archopht.1975.01010020520007.
Using the Greene melanoma in the hamster (Syrian Golden), the radiopharmaceutical, 123-1-4(3-dimethylaminopropylamino)-7-Iodoquinoline, was tested for its ability to localize melanoma. This quinoline analog has been described for use in the detection of melanoma, but this is the first report, to our knowledge, of its being used with an 123-l label. Hamsters with either skin or eye melanomas were studied. Both melanomas could be seen with a gamma camera at three hours after injection. In vitro analysis confirmed the tumor specificity. Thus, it appears that this preclinical trial of a new radiopharmaceutical justifies clinical testing to determine its value in the localization of melanomas of the eyes and skin of humans.
利用叙利亚金黄地鼠身上的格林氏黑色素瘤，对放射性药物123-I-4(3-二甲基氨基丙基氨基)-7-碘喹啉进行了黑色素瘤定位能力测试。这种喹啉类似物已被描述用于黑色素瘤检测，但据我们所知，这是其首次与123-I标记物一起使用的报告。研究了患有皮肤或眼部黑色素瘤的地鼠。注射后三小时，用γ相机可看到两种黑色素瘤。体外分析证实了肿瘤特异性。因此，看来这种新放射性药物的临床前试验证明了进行临床试验以确定其在人类眼部和皮肤黑色素瘤定位中的价值是合理的。
