[细胞因子在糖尿病视网膜病变发病机制中的作用]
[The role of cytokines in the pathogenesis of diabetic retinopathy].
作者信息
Ohara K, Funatsu H, Kitano S, Hori S, Yamashita H
机构信息
Department of Ophthalmology, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan.
出版信息
Nippon Ganka Gakkai Zasshi. 2001 Apr;105(4):213-7.
PURPOSE
To investigate the role of cytokines and advanced glycation end products(AGEs) in the pathogenesis of diabetic retinopathy, we measured vascular endothelial growth factor(VEGF), interleukin-6(IL-6), tumor necrosis factor-alpha(TNF-alpha), transforming growth factor-beta 1(TGF-beta 1), and pentosidine(an AGE) levels in aqueous, vitreous, and paired plasma obtained from diabetic patients.
RESULTS
The aqueous levels of VEGF and IL-6 were positively correlated with the grade of clinical severity of diabetic retinopathy (both VEGF and IL-6, p < 0.001). Other cytokines and pentosidine levels were not significantly associated. The aqueous levels of VEGF and IL-6 were higher than the plasma levels(VEGF p = 0.02, IL-6 p < 0.001).
CONCLUSION
Within the intraocular area VEGF and IL-6 are produced and participate in the pathogenesis of hyperpermeability of retinal vessels in preproliferative diabetic retinopathy.
目的
为了研究细胞因子和晚期糖基化终产物（AGEs）在糖尿病性视网膜病变发病机制中的作用，我们检测了糖尿病患者房水、玻璃体及配对血浆中血管内皮生长因子（VEGF）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、转化生长因子-β1（TGF-β1）以及戊糖苷（一种AGE）的水平。
结果
房水中VEGF和IL-6的水平与糖尿病性视网膜病变的临床严重程度分级呈正相关（VEGF和IL-6均为p < 0.001）。其他细胞因子和戊糖苷水平无显著相关性。房水中VEGF和IL-6的水平高于血浆水平（VEGF p = 0.02，IL-6 p < 0.001）。
结论
在眼内区域，VEGF和IL-6产生并参与增殖前期糖尿病性视网膜病变中视网膜血管高通透性的发病机制。
Zotero 插件