[人玻璃体中血管内皮生长因子与晚期糖基化终产物之间的关系]

[Relationship between vascular endothelial growth factors and advanced glycation end products in the human vitreous].

作者信息

Hashimoto H, Arai K, Chikuda M, Obara Y

机构信息

Department of Ophthalmology, Koshigaya Hospital, Dokkyo University School of Medicine, Japan.

出版信息

Nippon Ganka Gakkai Zasshi. 1998 Jul;102(7):442-6.

PMID:9720366

Abstract

The relation between vascular endothelial growth factor (VEGF) and advanced glycation end product (AGE) is considered a primary factor in the development of diabetic retinopathy. Regarding the relation between VEGF in the vitreous body and pentosidine, an AGE, we compared a diabetic (DM) group (7 eyes) with a nondiabetic (nonDM) group (7 eyes), and investigated the correlation between VEGF and pentosidine by calculating the correlation coefficient. Levels of both VEGF and pentosidine were significantly higher in the DM group (p < 0.01, p < 0.05), and a positive correlation was observed between the levels of VEGF and pentosidine (r = 0.770, p < 0.001). Since it is clear that there is a relation between VEGF and pentosidine in the vitreous body, we speculated that AGE is related to the secretion of cytokine in patients with diabetic retinopathy, and that it affects the development and progression of the disease.

摘要

血管内皮生长因子（VEGF）与晚期糖基化终产物（AGE）之间的关系被认为是糖尿病视网膜病变发展的主要因素。关于玻璃体中的VEGF与一种AGE——戊糖苷之间的关系，我们将糖尿病（DM）组（7只眼）与非糖尿病（nonDM）组（7只眼）进行了比较，并通过计算相关系数来研究VEGF与戊糖苷之间的相关性。DM组中VEGF和戊糖苷的水平均显著更高（p < 0.01，p < 0.05），并且在VEGF和戊糖苷水平之间观察到正相关（r = 0.770，p < 0.001）。由于玻璃体中VEGF与戊糖苷之间存在关系这一点很明确，我们推测AGE与糖尿病视网膜病变患者细胞因子的分泌有关，并且它影响该疾病的发展和进展。