系统性红斑狼疮患者体内的淋巴细胞毒性抗体。
Lymphocytotoxic antibodies in patients with systemic lupus erythematosus.
作者信息
Ooi B S, Orlina A R, Pesce A J, Mendoza N, Masaitis L, Pollak V E
出版信息
Clin Exp Immunol. 1974 Jun;17(2):237-43.
Abstract
Lymphocytotoxic activity could be demonstrated in the sera of patients with systemic lupus erythematosus. The number of positive reactions varied with temperature of incubation. Lymphocytotoxicity was present in 88%, 49% and 11% of sera tested at 15°C, 22°C and 37°C respectively. At an incubation temperature of 22°C, the presence of the lymphocytotoxic antibody in the sera could be correlated with significantly higher titres of anti-nuclear factor, anti-single-stranded DNA and the histological appearance of active diffuse glomerulonephritis in renal biopsies.
摘要
系统性红斑狼疮患者的血清中可显示出淋巴细胞毒性活性。阳性反应的数量随孵育温度而变化。分别在15°C、22°C和37°C下检测的血清中，淋巴细胞毒性的出现率分别为88%、49%和11%。在22°C的孵育温度下，血清中淋巴细胞毒性抗体的存在与抗核因子、抗单链DNA的显著更高滴度以及肾活检中活动性弥漫性肾小球肾炎的组织学表现相关。
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