Pyle G F, Oreskovic S, Begovac J, Thompson C
Department of Health Promotion and Kinesiology University of North Carolina at Charlotte, NC, USA.
Eur J Epidemiol. 2000;16(10):927-36. doi: 10.1023/a:1011010602831.
This study examines the presence of hepatitis B as a possible precursor marker for HIV/AIDS in 10 districts of Zagreb, Croatia. There were a total of 931 cases of hepatitis B in Zagreb in the period 1979-1995, the annual rate ranging from 3.1 to 15.4 per 10,000. The highest relative risk for hepatitis B for the 1979-1995 period was in the Pescenica district (Relative risk (RR): 1.4). There were 108 cases of HIV/AIDS diagnosed in Croatia in the period 1986-1996, with 34% from Zagreb. The highest relative risk for HIV/AIDS was within the Pescenica district (RR: 2.3). Pescenica had also a significantly higher incidence of hepatitis B when compared to other districts (p = 0.005). The cumulative incidence of hepatitis B in Zagreb was directly related to levels of neighborhood discomfort as determined by an index including unemployment, inflation and housing conditions (p = 0.005). This research demonstrates that the poor areas of the city with higher incidence of hepatitis B hold the greatest threat for the spread of HIV/AIDS.
本研究调查了克罗地亚萨格勒布10个区乙型肝炎作为人类免疫缺陷病毒/获得性免疫综合征（HIV/AIDS）可能的前驱标志物的情况。1979年至1995年期间，萨格勒布共有931例乙型肝炎病例，年发病率为每10000人3.1至15.4例。1979年至1995年期间，佩斯切尼察区乙型肝炎的相对风险最高（相对风险（RR）：1.4）。1986年至1996年期间，克罗地亚共诊断出108例HIV/AIDS病例，其中34%来自萨格勒布。HIV/AIDS的最高相对风险在佩斯切尼察区（RR：2.3）。与其他区相比，佩斯切尼察区的乙型肝炎发病率也显著更高（p = 0.005）。萨格勒布乙型肝炎的累积发病率与一个包括失业、通货膨胀和住房条件的指数所确定的邻里不适程度直接相关（p = 0.005）。这项研究表明，乙型肝炎发病率较高的城市贫困地区对HIV/AIDS的传播构成最大威胁。
