γ-谷氨酰转移酶是幽门螺杆菌的一种毒力因子，但对其定植并非必需。
gamma-Glutamyltransferase is a Helicobacter pylori virulence factor but is not essential for colonization.
作者信息
McGovern K J, Blanchard T G, Gutierrez J A, Czinn S J, Krakowka S, Youngman P
机构信息
Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts, USA.
出版信息
Infect Immun. 2001 Jun;69(6):4168-73. doi: 10.1128/IAI.69.6.4168-4173.2001.
Abstract
The contribution of glutamyl transpeptidase (GGT) (gamma-glutamyltransferase [EC 2. 3. 2. 2]) to Helicobacter pylori virulence was investigated in piglets and mice using GGT-deficient isogenic strains. All animals became colonized. However, the bacterial load was significantly lower for mutant bacteria than for parent strains. These results suggest that GGT activity provides an advantage to H. pylori in colonization.
摘要
利用谷氨酰胺转肽酶（GGT）（γ-谷氨酰转移酶[EC 2.3.2.2]）基因缺失的同基因菌株，在仔猪和小鼠中研究了GGT对幽门螺杆菌毒力的作用。所有动物均被定植。然而，突变菌的细菌载量显著低于亲本菌株。这些结果表明，GGT活性为幽门螺杆菌在定植过程中提供了优势。
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