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gamma-Glutamyltransferase is a Helicobacter pylori virulence factor but is not essential for colonization.

作者信息

McGovern K J, Blanchard T G, Gutierrez J A, Czinn S J, Krakowka S, Youngman P

机构信息

Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts, USA.

出版信息

Infect Immun. 2001 Jun;69(6):4168-73. doi: 10.1128/IAI.69.6.4168-4173.2001.

DOI:10.1128/IAI.69.6.4168-4173.2001
PMID:11349094
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC98487/
Abstract

The contribution of glutamyl transpeptidase (GGT) (gamma-glutamyltransferase [EC 2. 3. 2. 2]) to Helicobacter pylori virulence was investigated in piglets and mice using GGT-deficient isogenic strains. All animals became colonized. However, the bacterial load was significantly lower for mutant bacteria than for parent strains. These results suggest that GGT activity provides an advantage to H. pylori in colonization.

摘要

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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
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