幽门螺杆菌γ-谷氨酰转肽酶及其致病作用。
Helicobacter pylori gamma-glutamyl transpeptidase and its pathogenic role.
作者信息
Ricci Vittorio, Giannouli Maria, Romano Marco, Zarrilli Raffaele
机构信息
Vittorio Ricci, Department of Molecular Medicine, Human Physiology Section, University of Pavia Medical School, 27100 Pavia, Italy.
出版信息
World J Gastroenterol. 2014 Jan 21;20(3):630-8. doi: 10.3748/wjg.v20.i3.630.
Abstract
Helicobacter pylori (H. pylori) gamma-glutamyl transpeptidase (GGT) is a bacterial virulence factor that converts glutamine into glutamate and ammonia, and converts glutathione into glutamate and cysteinylglycine. H. pylori GGT causes glutamine and glutathione consumption in the host cells, ammonia production and reactive oxygen species generation. These products induce cell-cycle arrest, apoptosis, and necrosis in gastric epithelial cells. H. pylori GGT may also inhibit apoptosis and induce gastric epithelial cell proliferation through the induction of cyclooxygenase-2, epidermal growth factor-related peptides, inducible nitric oxide synthase and interleukin-8. H. pylori GGT induces immune tolerance through the inhibition of T cell-mediated immunity and dendritic cell differentiation. The effect of GGT on H. pylori colonization and gastric persistence are also discussed.
摘要
幽门螺杆菌（H. pylori）γ-谷氨酰转肽酶（GGT）是一种细菌毒力因子，可将谷氨酰胺转化为谷氨酸和氨，并将谷胱甘肽转化为谷氨酸和半胱氨酰甘氨酸。幽门螺杆菌GGT会导致宿主细胞内谷氨酰胺和谷胱甘肽的消耗、氨的产生以及活性氧的生成。这些产物会诱导胃上皮细胞发生细胞周期停滞、凋亡和坏死。幽门螺杆菌GGT还可能通过诱导环氧合酶-2、表皮生长因子相关肽、诱导型一氧化氮合酶和白细胞介素-8来抑制凋亡并诱导胃上皮细胞增殖。幽门螺杆菌GGT通过抑制T细胞介导的免疫和树突状细胞分化来诱导免疫耐受。文中还讨论了GGT对幽门螺杆菌定植和胃内持续存在的影响。
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