幽门螺杆菌、γ-谷氨酰转移酶与癌症：更多有趣的关联
Helicobacter, gamma-glutamyltransferase and cancer: further intriguing connections.
作者信息
Franzini Maria, Corti Alessandro, Fierabracci Vanna, Pompella Alfonso
机构信息
Maria Franzini, Alessandro Corti, Vanna Fierabracci, Alfonso Pompella, Department of Translational Research NTMC, University of Pisa Medical School, 56126 Pisa, Italy.
出版信息
World J Gastroenterol. 2014 Dec 21;20(47):18057-8. doi: 10.3748/wjg.v20.i47.18057.
Abstract
Virulence of Helicobacter pylori, Helicobacter suis and other bacteria appears to be partly mediated through a release of gamma-glutamyltransferase (GGT), an enzyme activity capable of promoting biochemical reactions ultimately resulting in damage to gastric epithelium and suppression of immune response. Recently published studies show that secretion of bacterial GGT occurs in the form of exosome-like vesicles. Very similar GGT-rich exosomes have been described to originate from human cancer cells, and the hypothesis is thus forwarded that in the resistant and invasive phenotype of malignant cells such vesicular/exosomal GGT may play roles akin to those described for Helicobacter infection, thus providing a significant contribution to the establishment of cancer metastases.
摘要
幽门螺杆菌、猪幽门螺杆菌及其他细菌的毒力似乎部分是通过γ-谷氨酰转移酶（GGT）的释放介导的，该酶活性能够促进生化反应，最终导致胃上皮损伤和免疫反应抑制。最近发表的研究表明，细菌GGT以类似外泌体的囊泡形式分泌。已经描述了非常相似的富含GGT的外泌体源自人类癌细胞，因此提出了这样的假设，即在恶性细胞的耐药和侵袭表型中，这种囊泡/外泌体GGT可能发挥类似于幽门螺杆菌感染所描述的作用，从而对癌症转移的形成做出重大贡献。
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