Faber S C, Eckstein F, Lukasz S, Mühlbauer R, Hohe J, Englmeier K H, Reiser M
Department of Clinical Radiology, Klinikum, University of Munich, Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany.
Skeletal Radiol. 2001 Mar;30(3):144-50. doi: 10.1007/s002560000320.
To compare the cartilage thickness, volume, and articular surface areas of the knee joint between young healthy, non-athletic female and male individuals.
MR imaging was performed in 18 healthy subjects without local or systemic joint disease (9 female, age 22.3 +/- 2.4 years, and 9 male, age 22.2 +/- 1.9 years.), using a fat-suppressed FLASH 3D pulse sequence (TR = 41 ms, TE = 11 ms, FA = 30 degrees) with sagittal orientation and a spatial resolution of 2 x 0.31 x 0.31 mm3. After three-dimensional reconstruction and triangulation of the knee joint cartilage plates, the cartilage thickness (mean and maximal), volume, and size of the articular surface area were quantified, independent of the original section orientation.
Women displayed smaller cartilage volumes than men, the percentage difference ranging from 19.9% in the patella, to 46.6% in the medial tibia. The gender differences of the cartilage thickness were smaller, ranging from 2.0% in the femoral trochlea to 13.3% in the medial tibia for the mean thickness, and from 4.3% in the medial femoral condyle to 18.3% in the medial tibia for the maximal cartilage thickness. The differences between the cartilage surface areas were similar to those of the volumes, with values ranging from 21.0% in the femur to 33.4% in the lateral tibia. Gender differences could be reduced for cartilage volume and surface area when normalized to body weight and body weight x body height. The study demonstrates significant gender differences in cartilage volume and surface area of men and women, which need to be taken into account when retrospectively estimating articular cartilage loss in patients with symptoms of degenerative joint disease. Differences in cartilage volume are primarily due to differences in joint surface areas (epiphyseal bone size), not to differences in cartilage thickness.
比较年轻健康、非运动员的女性和男性个体膝关节的软骨厚度、体积及关节表面积。
对18名无局部或全身性关节疾病的健康受试者（9名女性，年龄22.3±2.4岁；9名男性，年龄22.2±1.9岁）进行磁共振成像检查，采用脂肪抑制快速小角度激发三维脉冲序列（重复时间=41毫秒，回波时间=11毫秒，翻转角=30度），矢状位方向，空间分辨率为2×0.31×0.31立方毫米。在对膝关节软骨板进行三维重建和三角测量后，对软骨厚度（平均值和最大值）以及关节表面积的体积和大小进行量化，与原始切片方向无关。
女性的软骨体积小于男性，百分比差异从髌骨的19.9%到胫骨内侧的46.6%不等。软骨厚度的性别差异较小，平均厚度从股骨滑车的2.0%到胫骨内侧的13.3%，最大软骨厚度从股骨内侧髁的4.3%到胫骨内侧的18.3%。软骨表面积的差异与体积差异相似，股骨为21.0%，胫骨外侧为33.4%。当按体重和体重×身高进行归一化处理时，软骨体积和表面积的性别差异会减小。该研究表明，男性和女性的软骨体积和表面积存在显著性别差异，在回顾性评估退行性关节病症状患者的关节软骨损失时需要考虑到这一点。软骨体积的差异主要是由于关节表面积（骨骺骨大小）的差异，而非软骨厚度的差异。
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