Eckstein F, Winzheimer M, Westhoff J, Schnier M, Haubner M, Englmeier K H, Reiser M, Putz R
Anatomische Anstalt, Ludwig-Maximilians Universität, München, Germany.
Anat Embryol (Berl). 1998 May;197(5):383-90. doi: 10.1007/s004290050149.
The objective of this study was to assess the normal range of cartilage volumes in the knee joints of healthy adults, the ratio between the patellar, femoral, and tibial cartilages, and the correlation of the volumes with age, body weight, height, body mass index (obesity), patellar bone size, and the diameter of the tibial head. We examined the knee joints of nine healthy volunteers and eleven normal post-mortem specimens with an age range of 24 to 82 years. The cartilage volumes of the patella, femur, medial tibia and the lateral tibia were quantified, using a fat-suppressed FLASH-3D sequence (resolution 2x0.31x0.31 mm3) and digital postprocessing, involving three-dimensional reconstruction. The mean total volume of the knee joint cartilage was 23,245 mm3, the relative standard deviation (CV%) 19%, and the range 16,341 to 33,988 mm3. In the patella, femur and tibia, the CV% amounted to between 22 and 25%. These joint surfaces occupied a relatively variable proportion of the total knee joint volume, the percentage of the patella being 11 to 22%, that of the femur 54 to 69%, that of the medial tibia 7 to 12%, and that of lateral tibia 11 to 16%. The volumes of the lateral tibia were systematically higher than those of the medial tibia (P<0.001). There was no significant correlation of the knee joint cartilage volume with age (r=+0.05), body weight (r=+0.38), height (r=+0.39) or body mass index (r=+0.29), but a relatively high correlation with the diameter of the tibial head (r=+0.78, P<0.001). After normalising the volumes to this diameter, the CV% of the total knee joint cartilage volume was reduced to 13%, its variation being 12 to 21% in the patella, femur and tibia. MRI is available for measuring cartilage volume during growth, functional adaptation, and tissue loss in degenerative joint disease. The study shows that a wide variation of cartilage volumes exists in the knee joints of normal adults. To reduce the variability between individuals, the cartilage volumes may be normalised to the head of the tibial diameter.
本研究的目的是评估健康成年人膝关节软骨体积的正常范围、髌股胫软骨之间的比例，以及这些体积与年龄、体重、身高、体重指数（肥胖）、髌骨大小和胫骨头直径之间的相关性。我们检查了9名健康志愿者和11个年龄在24至82岁之间的正常尸检标本的膝关节。使用脂肪抑制FLASH-3D序列（分辨率2x0.31x0.31 mm3）和数字后处理（包括三维重建）对髌骨、股骨、胫骨内侧和胫骨外侧的软骨体积进行量化。膝关节软骨的平均总体积为23,245 mm3，相对标准差（CV%）为19%，范围为16,341至33,988 mm3。在髌骨、股骨和胫骨中，CV%在22%至25%之间。这些关节面在膝关节总体积中所占比例相对可变，髌骨的比例为11%至22%，股骨为54%至69%，胫骨内侧为7%至12%，胫骨外侧为11%至16%。胫骨外侧的体积系统地高于胫骨内侧（P<0.001）。膝关节软骨体积与年龄（r=+0.05）、体重（r=+0.38）、身高（r=+0.39）或体重指数（r=+0.29）无显著相关性，但与胫骨头直径相关性较高（r=+0.78，P<0.001）。将体积按此直径进行归一化后，膝关节软骨总体积的CV%降至13%，在髌骨、股骨和胫骨中的变化为12%至21%。MRI可用于测量生长、功能适应和退行性关节疾病中组织丢失期间的软骨体积。该研究表明，正常成年人膝关节软骨体积存在广泛差异。为了减少个体之间的变异性，软骨体积可按胫骨头直径进行归一化。
