急性脑膜炎中的循环钠
Circulating sodium in acute meningitis.
作者信息
von Vigier R O, Colombo S M, Stoffel P B, Meregalli P, Truttmann A C, Bianchetti M G
机构信息
Department of Pediatrics, University of Bern, Switzerland.
出版信息
Am J Nephrol. 2001 Mar-Apr;21(2):87-90. doi: 10.1159/000046229.
BACKGROUND
In acute meningitis hyponatremia is common and traditionally attributed exclusively to inappropriate water retention. However, the exact mechanisms underlying hyponatremia are unknown.
METHODS
The files of 300 pediatric patients with acute bacterial (n = 190) or aseptic (n = 110) meningitides were retrospectively analyzed.
RESULTS
The plasma sodium level ranged from 122 to 148 mmol/l and was low (<133 mmol/l) in 97 patients. Fluid volume contraction was significantly more pronounced in hyponatremia (median 6.0. 10(-2)) than in normonatremia (median 2.0. 10(-2)). The fractional sodium excretion was less than 1.00. 10(-2) in the 26 hyponatremic children with this measurement.
CONCLUSION
In acute meningitis hyponatremia is not exclusively brought about by inappropriate water retention.
背景
在急性脑膜炎中，低钠血症很常见，传统上仅归因于不适当的水潴留。然而，低钠血症的确切机制尚不清楚。
方法
回顾性分析300例急性细菌性（n = 190）或无菌性（n = 110）脑膜炎儿科患者的病历。
结果
血浆钠水平在122至148 mmol/l之间，97例患者的血浆钠水平较低（<133 mmol/l）。低钠血症患者的液体容量收缩（中位数6.0×10⁻²）比正常钠血症患者（中位数2.0×10⁻²）明显更显著。在进行此项测量的26例低钠血症儿童中，钠排泄分数小于1.00×10⁻²。
结论
在急性脑膜炎中，低钠血症并非仅由不适当的水潴留引起。
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