Paris Descartes University, Paris, France.
Med Hypotheses. 2010 Jan;74(1):71-5. doi: 10.1016/j.mehy.2009.07.054. Epub 2009 Aug 18.
Over the past decade, new evidence has shown that vitamin D deficiency may contribute to the risk of developing a wide range of common chronic diseases that are different from the classic action on calcium and bone homeostasis. Acting through the vitamin D receptor, vitamin D can produce a wide array of favorable biological effects via genomic, non-genomic or intracrine mechanisms and, therefore, contributes to the improvement of human health in humans. We hypothesize that some of these effects may be even more critical during pregnancy. The focus of this paper is to review the data on the classic and non-classic actions of vitamin D with regards to pregnancy. It appears that vitamin D insufficiency during pregnancy is potentially associated with increased risk of preeclampsia, insulin resistance and gestational diabetes mellitus. Furthermore, experimental data also anticipate that vitamin D sufficiency is critical for fetal development, and especially for fetal brain development and immunological functions. Vitamin D deficiency during pregnancy may, therefore, not only impair maternal skeletal preservation and fetal skeletal formation but also be vital to the fetal "imprinting" that may affect chronic disease susceptibility soon after birth as well as later in life.
在过去的十年中，新的证据表明，维生素 D 缺乏可能会增加罹患一系列与经典的钙和骨稳态作用不同的常见慢性疾病的风险。维生素 D 通过维生素 D 受体发挥作用，通过基因组、非基因组或细胞内机制产生广泛的有利的生物学效应，从而有助于改善人类健康。我们假设这些作用中的一些在怀孕期间甚至更为关键。本文的重点是回顾与妊娠相关的维生素 D 的经典和非经典作用的数据。似乎怀孕期间维生素 D 不足可能与子痫前期、胰岛素抵抗和妊娠糖尿病的风险增加有关。此外，实验数据还表明，维生素 D 充足对于胎儿发育至关重要，尤其是对于胎儿大脑发育和免疫功能。因此，妊娠期间的维生素 D 缺乏不仅会损害母体骨骼的保存和胎儿骨骼的形成，而且对胎儿的“印记”也至关重要，这种印记可能会在出生后不久以及以后的生活中影响慢性疾病的易感性。
