Pasco Julie A, Wark John D, Carlin John B, Ponsonby Anne-Louise, Vuillermin Peter J, Morley Ruth
Epidemiology and Biostatistics Unit, Department of Clinical and Biomedical Sciences: Barwon Health, The University of Melbourne, Australia.
Med Hypotheses. 2008 Aug;71(2):266-9. doi: 10.1016/j.mehy.2008.01.033. Epub 2008 Apr 29.
Osteoporotic fractures, falls and obesity are major health problems in developed nations. Evidence suggests that there are antenatal factors predisposing to these conditions. Data are emerging from Australia and elsewhere to suggest that maternal vitamin D status in pregnancy affects intrauterine skeletal mineralisation and skeletal growth together with muscle development and adiposity. Given that low levels of vitamin D have been documented in many urbanised populations, including those in countries with abundant sunlight, an important issue for public health is whether maternal vitamin D insufficiency during pregnancy has adverse effects on offspring health. The developing fetus may be exposed to low levels of vitamin D during critical phases of development as a result of maternal hypovitaminosis D. We hypothesise that this may have adverse effects on offspring musculoskeletal health and other aspects of body composition. Further research focused on the implications of poor gestational vitamin D nutrition is warranted as these developmental effects are likely to have a sustained influence on health during childhood and in adult life. We suggest that there is a clear rationale for randomised clinical trials to assess the potential benefits and harmful effects of vitamin D supplementation during pregnancy.
骨质疏松性骨折、跌倒和肥胖是发达国家的主要健康问题。有证据表明，存在一些导致这些情况的产前因素。来自澳大利亚和其他地方的数据表明，孕期母亲的维生素D水平会影响子宫内骨骼矿化和骨骼生长，以及肌肉发育和肥胖。鉴于在许多城市化人群中，包括阳光充足国家的人群，都有维生素D水平低的记录，公共卫生的一个重要问题是孕期母亲维生素D不足是否会对后代健康产生不利影响。由于母亲维生素D缺乏，发育中的胎儿在发育关键阶段可能会暴露于低水平的维生素D中。我们假设这可能会对后代的肌肉骨骼健康和身体组成的其他方面产生不利影响。鉴于这些发育影响可能会对儿童期和成年期的健康产生持续影响，因此有必要进一步研究孕期维生素D营养状况不佳的影响。我们认为，进行随机临床试验以评估孕期补充维生素D的潜在益处和有害影响有明确的理论依据。
