Venkataraman Karunakaran Jeyaraman, Boominathan Suresh Krishna, Nagappan Ragavendran, Abraham Chris Susan, Kaliyaperumal Anbarasi, Nachimuthu Jayaprakash, Premkumar Modachur Muruganathan
Department of Conservative Dentistry, JKK Nataraja Dental College and Hospital, Komarapalayam, Tamil Nadu, India.
Department of Oral Medicine and Radiology, Faculty of Dental Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
J Pharm Bioallied Sci. 2021 Nov;13(Suppl 2):S1603-S1608. doi: 10.4103/jpbs.jpbs_310_21. Epub 2021 Nov 10.
This study aims to compare intraradicular smear layer removal efficacy of different concentrations of glycolic acid (GA), 17% ethylenediaminetetraacetic acid (EDTA), and 10% citric acid (CA) as final rinses in the canals of curved mesial root of mandibular first molars using the specific irrigant protocols.
Fifty-eight mandibular first permanent molars with 15°-30° of curvature of the mesial roots were selected, standardized, mesiobuccal canal prepared using the rotary instrumentation. Sodium hypochlorite was used as initial rinse solution (8 ml). The samples were divided into control ( = 5) (I - Normal saline and II - 17% EDTA) and experimental groups ( = 8) (Groups III, IV, V, VI, VII, and VIII) based on the type of final rinse solution (5 ml) used, i.e. 2.5% GA, 5% GA, 10% GA, 17% GA, 37% GA, and 10% CA. Samples were split buccolingually, dehydrated, splutter coated, and examined under a scanning electron microscope.
Group IV presented the least amounts of smear among the GA experimental groups at the apical, middle, and coronal one-thirds of the root canal with a mean value of 2.6 ± 1.012, and on comparison with Group II, the results were comparable, and no significant difference found statistically ( > 0.05).
The use of GA as final rinse solution for biomechanical preparation during endodontic therapy seems promising. Further evaluation in a clinical setting is recommended.
本研究旨在比较在特定冲洗方案下，不同浓度的乙醇酸（GA）、17%乙二胺四乙酸（EDTA）和10%柠檬酸（CA）作为下颌第一磨牙近中弯曲根管最终冲洗液时，去除根管内牙本质玷污层的效果。
选取58颗近中根弯曲度为15° - 30°的下颌第一恒磨牙，进行标准化处理，使用旋转器械预备近中颊根管。次氯酸钠用作初始冲洗液（8毫升）。根据最终冲洗液（5毫升）的类型，将样本分为对照组（n = 5）（I - 生理盐水和II - 17% EDTA）和实验组（n = 8）（III、IV、V、VI、VII和VIII组），即2.5% GA、5% GA、10% GA、17% GA、37% GA和10% CA。样本沿颊舌向劈开，脱水，溅射镀膜，然后在扫描电子显微镜下检查。
在GA实验组中，IV组在根管根尖、中部和冠部三分之一处的玷污层最少，平均值为2.6 ± 1.012，与II组相比，结果具有可比性，统计学上无显著差异（P > 0.05）。
在牙髓治疗中，使用GA作为生物力学预备的最终冲洗液似乎很有前景。建议在临床环境中进行进一步评估。
